UCK_CAEEL
ID UCK_CAEEL Reviewed; 248 AA.
AC Q17413;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Probable uridine-cytidine kinase;
DE Short=UCK;
DE EC=2.7.1.48;
DE AltName: Full=Cytidine monophosphokinase;
DE AltName: Full=Uridine monophosphokinase;
GN ORFNames=B0001.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + uridine = ADP + H(+) + UMP; Xref=Rhea:RHEA:16825,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16704, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57865, ChEBI:CHEBI:456216; EC=2.7.1.48;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + cytidine = ADP + CMP + H(+); Xref=Rhea:RHEA:24674,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17562, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:60377, ChEBI:CHEBI:456216; EC=2.7.1.48;
CC -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage pathway;
CC CTP from cytidine: step 1/3.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway;
CC UMP from uridine: step 1/1.
CC -!- SIMILARITY: Belongs to the uridine kinase family. {ECO:0000305}.
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DR EMBL; Z69634; CAA93453.2; -; Genomic_DNA.
DR PIR; T18629; T18629.
DR RefSeq; NP_502304.2; NM_069903.2.
DR AlphaFoldDB; Q17413; -.
DR SMR; Q17413; -.
DR BioGRID; 43253; 2.
DR IntAct; Q17413; 1.
DR STRING; 6239.B0001.4; -.
DR iPTMnet; Q17413; -.
DR EPD; Q17413; -.
DR PaxDb; Q17413; -.
DR PeptideAtlas; Q17413; -.
DR EnsemblMetazoa; B0001.4a.1; B0001.4a.1; WBGene00007089.
DR GeneID; 178160; -.
DR KEGG; cel:CELE_B0001.4; -.
DR UCSC; B0001.4; c. elegans.
DR CTD; 178160; -.
DR WormBase; B0001.4a; CE37307; WBGene00007089; -.
DR eggNOG; KOG4203; Eukaryota.
DR GeneTree; ENSGT01020000230412; -.
DR HOGENOM; CLU_021278_1_1_1; -.
DR InParanoid; Q17413; -.
DR OMA; TTLKPMH; -.
DR OrthoDB; 929897at2759; -.
DR PhylomeDB; Q17413; -.
DR Reactome; R-CEL-73614; Pyrimidine salvage.
DR UniPathway; UPA00574; UER00637.
DR UniPathway; UPA00579; UER00640.
DR PRO; PR:Q17413; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00007089; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR ExpressionAtlas; Q17413; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004849; F:uridine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0044211; P:CTP salvage; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway.
DR CDD; cd02023; UMPK; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006083; PRK/URK.
DR InterPro; IPR000764; Uridine_kinase-like.
DR Pfam; PF00485; PRK; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Transferase.
FT CHAIN 1..248
FT /note="Probable uridine-cytidine kinase"
FT /id="PRO_0000164459"
FT REGION 224..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 15..23
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 73
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 101
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 154
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 164
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 172
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 201
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 248 AA; 28390 MW; F404213A23CF7261 CRC64;
MKNTLKLPLL IGVAGGTSCG KSTIVERIIE NLNANAKQSG RQIDIVHLSL HSFYRELSAE
EKILAREGKF NFDHPDQINF DLLAETLQNM IDGKTVEIPK YDMITSSMNG TVTVEPAKVI
IIEGILLLYD ERVRKLLSTK LFVEKNAESR LRNRLATYIR DYHRAPLSII RQYTEFVKPA
FEEFCRPTKK YADVIIPRGA DNHVATDLIA KNLQETFRKI VVSSDEEEEK ENELVKQGSF
RRPFSRPH
