ID   UCMA_DANRE              Reviewed;         135 AA.
AC   Q6NWB6;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Unique cartilage matrix-associated protein;
DE   Contains:
DE     RecName: Full=Unique cartilage matrix-associated protein C-terminal fragment;
DE              Short=Ucma-C;
DE     AltName: Full=Gla-rich protein;
DE              Short=GRP;
DE   Flags: Precursor;
GN   Name=ucma; ORFNames=zgc:85838;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in the negative control of osteogenic
CC       differentiation of osteochondrogenic precursor cells in peripheral
CC       zones of fetal cartilage and at the cartilage-bone interface.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250}.
CC   -!- PTM: Proteolytically cleaved by a furin-like convertase to generate a
CC       persistent C-terminal fragment found in almost the entire cartilage
CC       matrix, and affecting osteoblast differentiation. {ECO:0000250}.
CC   -!- PTM: Sulfated on tyrosine residues. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UCMA family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC067652; AAH67652.1; -; mRNA.
DR   RefSeq; NP_998099.1; NM_212934.1.
DR   AlphaFoldDB; Q6NWB6; -.
DR   STRING; 7955.ENSDARP00000026630; -.
DR   PaxDb; Q6NWB6; -.
DR   Ensembl; ENSDART00000171904; ENSDARP00000135381; ENSDARG00000005485.
DR   GeneID; 405870; -.
DR   KEGG; dre:405870; -.
DR   CTD; 405870; -.
DR   ZFIN; ZDB-GENE-040426-2368; ucmab.
DR   eggNOG; ENOG502S1J9; Eukaryota.
DR   GeneTree; ENSGT00390000011492; -.
DR   HOGENOM; CLU_2637365_0_0_1; -.
DR   InParanoid; Q6NWB6; -.
DR   OMA; TMLQEGT; -.
DR   OrthoDB; 1577653at2759; -.
DR   PhylomeDB; Q6NWB6; -.
DR   TreeFam; TF332568; -.
DR   PRO; PR:Q6NWB6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 25.
DR   Bgee; ENSDARG00000005485; Expressed in larva and 21 other tissues.
DR   ExpressionAtlas; Q6NWB6; baseline.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0048706; P:embryonic skeletal system development; IMP:ZFIN.
DR   GO; GO:0045667; P:regulation of osteoblast differentiation; IEA:InterPro.
DR   InterPro; IPR031386; UCMA.
DR   PANTHER; PTHR28647; PTHR28647; 1.
DR   Pfam; PF17085; UCMA; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Extracellular matrix; Gamma-carboxyglutamic acid;
KW   Reference proteome; Secreted; Signal; Sulfation.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..135
FT                   /note="Unique cartilage matrix-associated protein"
FT                   /id="PRO_0000371310"
FT   PROPEP          28..61
FT                   /note="Ucma-N"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000371311"
FT   CHAIN           62..135
FT                   /note="Unique cartilage matrix-associated protein C-
FT                   terminal fragment"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000371312"
FT   REGION          65..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          64..114
FT                   /evidence="ECO:0000255"
FT   MOD_RES         68
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         72
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         81
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         85
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         88
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         89
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         95
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         99
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         100
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         104
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         107
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         111
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         114
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   135 AA;  16061 MW;  245077C085CF5550 CRC64;
     MSWTQPALLT CLLVLSAITL FDGADSAVSD KRDAVNPQGA LRKIFMPEAD AASFFKRRSR
     RAVKTQDEIN AEQRQRLAAD ERRREYHEEQ RNKYENYAEE ENDEQDERTR EKTEQWREFH
     YDGLDPSYEY NRHTI