UCN2_HUMAN
ID UCN2_HUMAN Reviewed; 112 AA.
AC Q96RP3; Q9BUG0;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Urocortin-2;
DE AltName: Full=Stresscopin-related peptide;
DE AltName: Full=Urocortin II;
DE Short=Ucn II;
DE AltName: Full=Urocortin-related peptide;
DE Flags: Precursor;
GN Name=UCN2; Synonyms=SRP, URP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11329063; DOI=10.1038/87936;
RA Hsu S.Y., Hsueh A.J.W.;
RT "Human stresscopin and stresscopin-related peptide are selective ligands
RT for the type 2 corticotropin-releasing hormone receptor.";
RL Nat. Med. 7:605-611(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP LACK OF AMIDATION.
RX PubMed=23493376; DOI=10.1210/en.2012-2011;
RA Vaughan J.M., Donaldson C.J., Fischer W.H., Perrin M.H., Rivier J.E.,
RA Sawchenko P.E., Vale W.W.;
RT "Posttranslational processing of human and mouse urocortin 2:
RT characterization and bioactivity of gene products.";
RL Endocrinology 154:1553-1564(2013).
RN [4]
RP STRUCTURE BY NMR OF 72-109.
RX PubMed=18052377; DOI=10.1021/ja0760933;
RA Grace C.R.R., Perrin M.H., Cantle J.P., Vale W.W., Rivier J.E., Riek R.;
RT "Common and divergent structural features of a series of corticotropin
RT releasing factor-related peptides.";
RL J. Am. Chem. Soc. 129:16102-16114(2007).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (2.72 ANGSTROMS) OF 94-109 IN COMPLEX WITH CRHR2.
RX PubMed=20966082; DOI=10.1074/jbc.m110.186072;
RA Pal K., Swaminathan K., Xu H.E., Pioszak A.A.;
RT "Structural basis for hormone recognition by the Human CRFR2{alpha} G
RT protein-coupled receptor.";
RL J. Biol. Chem. 285:40351-40361(2010).
CC -!- FUNCTION: Suppresses food intake, delays gastric emptying and decreases
CC heat-induced edema. Might represent an endogenous ligand for
CC maintaining homeostasis after stress.
CC -!- SUBUNIT: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
CC {ECO:0000269|PubMed:20966082}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- PTM: Glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC factor/urotensin I family. {ECO:0000305}.
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DR EMBL; AF320560; AAK52672.1; -; mRNA.
DR EMBL; BC002647; AAH02647.2; -; mRNA.
DR EMBL; BC022096; AAH22096.1; -; mRNA.
DR CCDS; CCDS2772.1; -.
DR RefSeq; NP_149976.1; NM_033199.3.
DR PDB; 2RMG; NMR; -; A=72-109.
DR PDB; 3N95; X-ray; 2.72 A; E/F=94-109.
DR PDBsum; 2RMG; -.
DR PDBsum; 3N95; -.
DR AlphaFoldDB; Q96RP3; -.
DR SMR; Q96RP3; -.
DR BioGRID; 124679; 2.
DR IntAct; Q96RP3; 2.
DR STRING; 9606.ENSP00000273610; -.
DR BioMuta; UCN2; -.
DR DMDM; 20532289; -.
DR MassIVE; Q96RP3; -.
DR PaxDb; Q96RP3; -.
DR PRIDE; Q96RP3; -.
DR Antibodypedia; 55296; 190 antibodies from 24 providers.
DR DNASU; 90226; -.
DR Ensembl; ENST00000273610.4; ENSP00000273610.3; ENSG00000145040.4.
DR GeneID; 90226; -.
DR KEGG; hsa:90226; -.
DR MANE-Select; ENST00000273610.4; ENSP00000273610.3; NM_033199.4; NP_149976.1.
DR UCSC; uc003cty.2; human.
DR CTD; 90226; -.
DR DisGeNET; 90226; -.
DR GeneCards; UCN2; -.
DR HGNC; HGNC:18414; UCN2.
DR HPA; ENSG00000145040; Tissue enhanced (skin, vagina).
DR MIM; 605902; gene.
DR neXtProt; NX_Q96RP3; -.
DR OpenTargets; ENSG00000145040; -.
DR PharmGKB; PA133787055; -.
DR VEuPathDB; HostDB:ENSG00000145040; -.
DR eggNOG; ENOG502R23K; Eukaryota.
DR GeneTree; ENSGT00940000160568; -.
DR HOGENOM; CLU_2145078_0_0_1; -.
DR InParanoid; Q96RP3; -.
DR OMA; QATPCPV; -.
DR PhylomeDB; Q96RP3; -.
DR TreeFam; TF330723; -.
DR PathwayCommons; Q96RP3; -.
DR Reactome; R-HSA-373080; Class B/2 (Secretin family receptors).
DR SignaLink; Q96RP3; -.
DR BioGRID-ORCS; 90226; 10 hits in 1063 CRISPR screens.
DR EvolutionaryTrace; Q96RP3; -.
DR GeneWiki; UCN2; -.
DR GenomeRNAi; 90226; -.
DR Pharos; Q96RP3; Tbio.
DR PRO; PR:Q96RP3; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q96RP3; protein.
DR Bgee; ENSG00000145040; Expressed in stromal cell of endometrium and 71 other tissues.
DR Genevisible; Q96RP3; HS.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0051431; F:corticotropin-releasing hormone receptor 2 binding; IEA:InterPro.
DR GO; GO:0051429; F:corticotropin-releasing hormone receptor binding; IPI:UniProtKB.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0042562; F:hormone binding; IPI:UniProtKB.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0031669; P:cellular response to nutrient levels; IBA:GO_Central.
DR GO; GO:0007586; P:digestion; NAS:UniProtKB.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IDA:UniProtKB.
DR InterPro; IPR000187; CRF.
DR InterPro; IPR024273; Urocortin_II.
DR InterPro; IPR024270; Urocortin_II/III.
DR PANTHER; PTHR17575; PTHR17575; 1.
DR PANTHER; PTHR17575:SF0; PTHR17575:SF0; 1.
DR Pfam; PF00473; CRF; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Glycoprotein; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000250"
FT PROPEP 23..70
FT /evidence="ECO:0000250"
FT /id="PRO_0000006239"
FT CHAIN 72..112
FT /note="Urocortin-2"
FT /id="PRO_0000006240"
FT REGION 27..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 80..88
FT /evidence="ECO:0007829|PDB:2RMG"
FT HELIX 95..108
FT /evidence="ECO:0007829|PDB:3N95"
SQ SEQUENCE 112 AA; 12146 MW; 0EFF29A3463723D4 CRC64;
MTRCALLLLM VLMLGRVLVV PVTPIPTFQL RPQNSPQTTP RPAASESPSA APTWPWAAQS
HCSPTRHPGS RIVLSLDVPI GLLQILLEQA RARAAREQAT TNARILARVG HC
