ID   UCN2_RAT                Reviewed;         109 AA.
AC   Q91WW1;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 121.
DE   RecName: Full=Urocortin-2;
DE   AltName: Full=Urocortin II;
DE            Short=Ucn II;
DE   Flags: Precursor;
GN   Name=Ucn2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Midbrain;
RA   Park J.H., Ju S.K., Lee M.K.;
RT   "Cloning and analysis of tissue-specific mRNA expression of rat urocortin
RT   II.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Suppresses food intake, delays gastric emptying and decreases
CC       heat-induced edema. Might represent an endogenous ligand for
CC       maintaining homeostasis after stress (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Glycosylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   EMBL; AY044835; AAK98780.1; -; mRNA.
DR   AlphaFoldDB; Q91WW1; -.
DR   SMR; Q91WW1; -.
DR   STRING; 10116.ENSRNOP00000028031; -.
DR   PaxDb; Q91WW1; -.
DR   UCSC; RGD:620765; rat.
DR   RGD; 620765; Ucn2.
DR   eggNOG; ENOG502R23K; Eukaryota.
DR   HOGENOM; CLU_2145078_0_0_1; -.
DR   InParanoid; Q91WW1; -.
DR   OMA; QATPCPV; -.
DR   TreeFam; TF330723; -.
DR   Reactome; R-RNO-373080; Class B/2 (Secretin family receptors).
DR   PRO; PR:Q91WW1; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Genevisible; Q91WW1; RN.
DR   GO; GO:0005615; C:extracellular space; IDA:RGD.
DR   GO; GO:0051431; F:corticotropin-releasing hormone receptor 2 binding; IPI:RGD.
DR   GO; GO:0051429; F:corticotropin-releasing hormone receptor binding; ISS:UniProtKB.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; ISO:RGD.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0042562; F:hormone binding; ISO:RGD.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISO:RGD.
DR   GO; GO:0008283; P:cell population proliferation; IDA:RGD.
DR   GO; GO:0071385; P:cellular response to glucocorticoid stimulus; IEP:RGD.
DR   GO; GO:0071456; P:cellular response to hypoxia; IEP:RGD.
DR   GO; GO:0031669; P:cellular response to nutrient levels; IBA:GO_Central.
DR   GO; GO:0007586; P:digestion; IEA:InterPro.
DR   GO; GO:0009755; P:hormone-mediated signaling pathway; ISO:RGD.
DR   GO; GO:0046882; P:negative regulation of follicle-stimulating hormone secretion; IMP:RGD.
DR   GO; GO:0010629; P:negative regulation of gene expression; IMP:RGD.
DR   GO; GO:0033685; P:negative regulation of luteinizing hormone secretion; IMP:RGD.
DR   GO; GO:0035902; P:response to immobilization stress; IEP:RGD.
DR   GO; GO:0042246; P:tissue regeneration; TAS:RGD.
DR   InterPro; IPR000187; CRF.
DR   InterPro; IPR024273; Urocortin_II.
DR   InterPro; IPR024270; Urocortin_II/III.
DR   PANTHER; PTHR17575; PTHR17575; 1.
DR   PANTHER; PTHR17575:SF0; PTHR17575:SF0; 1.
DR   Pfam; PF00473; CRF; 1.
PE   3: Inferred from homology;
KW   Amidation; Glycoprotein; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..67
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000006243"
FT   CHAIN           69..106
FT                   /note="Urocortin-2"
FT                   /id="PRO_0000006244"
FT   REGION          24..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         106
FT                   /note="Valine amide; partial"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   109 AA;  11922 MW;  AA2B46D8903ED83E CRC64;
     MTRWALVVFM VLMLDRVPGT PIPTFQLLPQ NYPETTPSSV SSESPSDTTT GPSASWSNSK
     ASPYLDTRVI LSLDVPIGLL RILLEQARNK AARNQAATNA QILARVGRR