ID   UCN3_BOVIN              Reviewed;         166 AA.
AC   Q1RMJ9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Urocortin-3;
DE   AltName: Full=Urocortin III;
DE            Short=Ucn III;
DE   Flags: Precursor;
GN   Name=UCN3; Synonyms=SPC;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Suppresses food intake, delays gastric emptying and decreases
CC       heat-induced edema. Might represent an endogenous ligand for
CC       maintaining homeostasis after stress (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   EMBL; BC114855; AAI14856.1; -; mRNA.
DR   RefSeq; NP_001069995.1; NM_001076527.1.
DR   AlphaFoldDB; Q1RMJ9; -.
DR   SMR; Q1RMJ9; -.
DR   STRING; 9913.ENSBTAP00000046927; -.
DR   PaxDb; Q1RMJ9; -.
DR   Ensembl; ENSBTAT00000050183; ENSBTAP00000046927; ENSBTAG00000035696.
DR   GeneID; 751573; -.
DR   KEGG; bta:751573; -.
DR   CTD; 114131; -.
DR   VEuPathDB; HostDB:ENSBTAG00000035696; -.
DR   VGNC; VGNC:36639; UCN3.
DR   eggNOG; ENOG502S1WZ; Eukaryota.
DR   GeneTree; ENSGT00940000160568; -.
DR   InParanoid; Q1RMJ9; -.
DR   OMA; KFYKAKP; -.
DR   OrthoDB; 1568003at2759; -.
DR   Proteomes; UP000009136; Chromosome 13.
DR   Bgee; ENSBTAG00000035696; Expressed in midbrain and 2 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0051431; F:corticotropin-releasing hormone receptor 2 binding; IEA:InterPro.
DR   GO; GO:0051429; F:corticotropin-releasing hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0031669; P:cellular response to nutrient levels; IBA:GO_Central.
DR   GO; GO:0007586; P:digestion; IEA:InterPro.
DR   GO; GO:0009755; P:hormone-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR000187; CRF.
DR   InterPro; IPR024270; Urocortin_II/III.
DR   PANTHER; PTHR17575; PTHR17575; 1.
DR   Pfam; PF00473; CRF; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..123
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000318943"
FT   CHAIN           125..162
FT                   /note="Urocortin-3"
FT                   /id="PRO_0000318944"
FT   REGION          41..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         162
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   166 AA;  17849 MW;  1595B7C69B7CBC2B CRC64;
     MLVPAPFLLV LLLLLGAPQV GLSQRSPKAG SSPSCLHTAL REAEKSQRKD TSLLIKRTFP
     ALPRGDPEDQ EGQEEEDTEK RTFPGSVGGG GGGGAGSTRY KYPSQAQFQG RPSQDKAKSD
     RRTKVTLSLD VPTNIMNILF NIAKAKNLRA KAAANAHLMA QIGRKK