UCN3_MOUSE
ID UCN3_MOUSE Reviewed; 164 AA.
AC Q924A4;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Urocortin-3;
DE AltName: Full=Urocortin III;
DE Short=Ucn III;
DE Flags: Precursor;
GN Name=Ucn3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], SYNTHESIS OF UCN III, AND TISSUE
RP SPECIFICITY.
RX PubMed=11416224; DOI=10.1073/pnas.121165198;
RA Lewis K., Li C., Perrin M.H., Blount A., Kunitake K., Donaldson C.,
RA Vaughan J., Reyes T.M., Gulyas J., Fischer W., Bilezikjian L., Rivier J.,
RA Sawchenko P.E., Vale W.W.;
RT "Identification of urocortin III, an additional member of the
RT corticotropin-releasing factor (CRF) family with high affinity for the CRF2
RT receptor.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7570-7575(2001).
CC -!- FUNCTION: Suppresses food intake, delays gastric emptying and decreases
CC heat-induced edema. Might represent an endogenous ligand for
CC maintaining homeostasis after stress (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in some areas of the brain including the
CC hypothalamus, amygdala, and brainstem, but is not evident in the
CC cerebellum, pituitary, or cerebral cortex; it is also expressed
CC peripherally in small intestine and skin.
CC {ECO:0000269|PubMed:11416224}.
CC -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC factor/urotensin I family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF361944; AAK67318.1; -; Genomic_DNA.
DR CCDS; CCDS26217.1; -.
DR RefSeq; NP_112540.2; NM_031250.5.
DR AlphaFoldDB; Q924A4; -.
DR SMR; Q924A4; -.
DR BioGRID; 219919; 2.
DR STRING; 10090.ENSMUSP00000049678; -.
DR PhosphoSitePlus; Q924A4; -.
DR PaxDb; Q924A4; -.
DR PRIDE; Q924A4; -.
DR ProteomicsDB; 300189; -.
DR Antibodypedia; 24078; 165 antibodies from 27 providers.
DR Ensembl; ENSMUST00000058610; ENSMUSP00000049678; ENSMUSG00000044988.
DR GeneID; 83428; -.
DR KEGG; mmu:83428; -.
DR UCSC; uc007pjh.2; mouse.
DR CTD; 114131; -.
DR MGI; MGI:1932970; Ucn3.
DR VEuPathDB; HostDB:ENSMUSG00000044988; -.
DR eggNOG; ENOG502S1WZ; Eukaryota.
DR GeneTree; ENSGT00940000160568; -.
DR HOGENOM; CLU_1767442_0_0_1; -.
DR InParanoid; Q924A4; -.
DR OMA; KFYKAKP; -.
DR OrthoDB; 1568003at2759; -.
DR PhylomeDB; Q924A4; -.
DR TreeFam; TF330723; -.
DR Reactome; R-MMU-373080; Class B/2 (Secretin family receptors).
DR BioGRID-ORCS; 83428; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q924A4; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q924A4; protein.
DR Bgee; ENSMUSG00000044988; Expressed in islet of Langerhans and 6 other tissues.
DR ExpressionAtlas; Q924A4; baseline and differential.
DR Genevisible; Q924A4; MM.
DR GO; GO:0030424; C:axon; ISO:MGI.
DR GO; GO:0043679; C:axon terminus; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; ISO:MGI.
DR GO; GO:0043196; C:varicosity; ISO:MGI.
DR GO; GO:0051431; F:corticotropin-releasing hormone receptor 2 binding; IEA:InterPro.
DR GO; GO:0051429; F:corticotropin-releasing hormone receptor binding; ISO:MGI.
DR GO; GO:0005184; F:neuropeptide hormone activity; TAS:MGI.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:MGI.
DR GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
DR GO; GO:0031669; P:cellular response to nutrient levels; IBA:GO_Central.
DR GO; GO:0007586; P:digestion; IEA:InterPro.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; ISO:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; TAS:MGI.
DR GO; GO:0032024; P:positive regulation of insulin secretion; ISO:MGI.
DR GO; GO:0045838; P:positive regulation of membrane potential; ISO:MGI.
DR GO; GO:0051412; P:response to corticosterone; IEA:Ensembl.
DR GO; GO:0009749; P:response to glucose; IEA:Ensembl.
DR GO; GO:0035902; P:response to immobilization stress; IEA:Ensembl.
DR GO; GO:0042594; P:response to starvation; IEA:Ensembl.
DR InterPro; IPR000187; CRF.
DR InterPro; IPR024270; Urocortin_II/III.
DR PANTHER; PTHR17575; PTHR17575; 1.
DR Pfam; PF00473; CRF; 1.
PE 2: Evidence at transcript level;
KW Amidation; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..121
FT /id="PRO_0000006247"
FT CHAIN 123..160
FT /note="Urocortin-3"
FT /id="PRO_0000006248"
FT REGION 58..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 160
FT /note="Isoleucine amide"
FT /evidence="ECO:0000255"
SQ SEQUENCE 164 AA; 18063 MW; 93A77CB93DA56E5C CRC64;
MLMPTYFLLP LLLLLGGPRT SLSHKFYNTG PVFSCLNTAL SEVKKNKLED VPLLSKKSFG
HLPTQDPSGE EDDNQTHLQI KRTFSGAAGG NGAGSTRYRY QSQAQHKGKL YPDKPKSDRG
TKFTLSLDVP TNIMNILFNI DKAKNLRAKA AANAQLMAQI GKKK
