ID   UCP10_SCHPO             Reviewed;         427 AA.
AC   O74498;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=UBX domain-containing protein 10;
GN   Name=ucp10; ORFNames=SPCC285.11;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Involved in protein degradation through the
CC       ubiquitin/proteasome pathway. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000269|PubMed:16823372}.
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DR   EMBL; CU329672; CAA20850.1; -; Genomic_DNA.
DR   PIR; T41257; T41257.
DR   RefSeq; NP_588339.1; NM_001023330.2.
DR   AlphaFoldDB; O74498; -.
DR   SMR; O74498; -.
DR   BioGRID; 275830; 78.
DR   STRING; 4896.SPCC285.11.1; -.
DR   MaxQB; O74498; -.
DR   PaxDb; O74498; -.
DR   EnsemblFungi; SPCC285.11.1; SPCC285.11.1:pep; SPCC285.11.
DR   GeneID; 2539260; -.
DR   KEGG; spo:SPCC285.11; -.
DR   PomBase; SPCC285.11; -.
DR   VEuPathDB; FungiDB:SPCC285.11; -.
DR   eggNOG; KOG1363; Eukaryota.
DR   HOGENOM; CLU_034590_0_0_1; -.
DR   InParanoid; O74498; -.
DR   OMA; HTLFWAC; -.
DR   PhylomeDB; O74498; -.
DR   Reactome; R-SPO-6798695; Neutrophil degranulation.
DR   Reactome; R-SPO-8980692; RHOA GTPase cycle.
DR   PRO; PR:O74498; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0044695; C:Dsc E3 ubiquitin ligase complex; IPI:PomBase.
DR   GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0032933; P:SREBP signaling pathway; IMP:PomBase.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR006577; UAS.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR001012; UBX_dom.
DR   Pfam; PF00789; UBX; 1.
DR   SMART; SM00594; UAS; 1.
DR   SMART; SM00166; UBX; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50033; UBX; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endoplasmic reticulum; Reference proteome;
KW   Ubl conjugation pathway.
FT   CHAIN           1..427
FT                   /note="UBX domain-containing protein 10"
FT                   /id="PRO_0000314760"
FT   DOMAIN          323..425
FT                   /note="UBX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00215"
FT   COILED          247..311
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   427 AA;  48671 MW;  3AA7E161BE1F7D90 CRC64;
     MSGSRKQEAI DELRNSLDVP ADTAQSVLES FNWDVQEAIE SLTGESSRVD RNSKLGLSFG
     VFQSVFSLLF SGLHKLWMIL SRVPLISTFI PIFGTTKRVL SPADTANKLV QNLEEQYGTE
     HIDFFTDGGY MEALTRIKRN YGVALLFFTS SKNDDSETFS RSVLMNQELK EFLNRRNILC
     WTGDVCEDEA FRGSRQFHCT KFPSAVLVMY SPQLSELVVA AQLHGCLDSS SIITNLTNAL
     AKHLPSLERF RSEREAREAA RELRRQQDNA YQASLARDRE RQAFARAEEE RLAKEKEERE
     IVQKKKKQYR AWLASNLPPE PSSEDEPARL SIRFPDGSRA VRRFKKDDTV ESVYNYVDYM
     LFEKEEPEEF GRATSSSNPV TPPSDYKHDF HFQLYSSLPR ALLKPSVAIS TNKAIFPNGT
     VVVELDD