位置:首页 > 蛋白库 > UCP1_CANLF
UCP1_CANLF
ID   UCP1_CANLF              Reviewed;         309 AA.
AC   Q9GMZ1;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Mitochondrial brown fat uncoupling protein 1 {ECO:0000305};
DE            Short=UCP 1 {ECO:0000305};
DE   AltName: Full=Solute carrier family 25 member 7 {ECO:0000250|UniProtKB:P25874};
DE   AltName: Full=Thermogenin {ECO:0000250|UniProtKB:P04575};
GN   Name=UCP1 {ECO:0000303|PubMed:11959030};
GN   Synonyms=SLC25A7 {ECO:0000250|UniProtKB:P25874};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Beagle;
RX   PubMed=11959030; DOI=10.1016/s1096-4959(02)00004-0;
RA   Ishioka K., Kanehira K., Sasaki N., Kitamura H., Kimura K., Saito M.;
RT   "Canine mitochondrial uncoupling proteins: structure and mRNA expression of
RT   three isoforms in adult beagles.";
RL   Comp. Biochem. Physiol. 131B:483-489(2002).
CC   -!- FUNCTION: Mitochondrial protein responsible for thermogenic
CC       respiration, a specialized capacity of brown adipose tissue and beige
CC       fat that participates in non-shivering adaptive thermogenesis to
CC       temperature and diet variations and more generally to the regulation of
CC       energy balance. Functions as a long-chain fatty acid/LCFA and proton
CC       symporter, simultaneously transporting one LCFA and one proton through
CC       the inner mitochondrial membrane. However, LCFAs remaining associated
CC       with the transporter via their hydrophobic tails, it results in an
CC       apparent transport of protons activated by LCFAs. Thereby, dissipates
CC       the mitochondrial proton gradient and converts the energy of substrate
CC       oxydation into heat instead of ATP. Regulates the production of
CC       reactive oxygen species/ROS by mitochondria.
CC       {ECO:0000250|UniProtKB:P12242}.
CC   -!- ACTIVITY REGULATION: Has no constitutive proton transporter activity
CC       and has to be activated by long-chain fatty acids/LCFAs. Inhibited by
CC       purine nucleotides. Both purine nucleotides and LCFAs bind the
CC       cytosolic side of the transporter and directly compete to activate or
CC       inhibit it. Activated by noradrenaline and reactive oxygen species.
CC       {ECO:0000250|UniProtKB:P12242}.
CC   -!- SUBUNIT: Most probably functions as a monomer. Binds one purine
CC       nucleotide per monomer. However, has also been suggested to function as
CC       a homodimer or a homotetramer. Tightly associates with cardiolipin in
CC       the mitochondrion inner membrane; may stabilize and regulate its
CC       activity. {ECO:0000250|UniProtKB:P25874, ECO:0000250|UniProtKB:W5PSH7}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P12242}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P04633}.
CC   -!- PTM: May undergo sulfenylation upon cold exposure. May increase the
CC       sensitivity of UCP1 thermogenic function to the activation by
CC       noradrenaline probably through structural effects.
CC       {ECO:0000250|UniProtKB:P12242}.
CC   -!- PTM: May undergo ubiquitin-mediated proteasomal degradation.
CC       {ECO:0000250|UniProtKB:P04633}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB046106; BAB11684.1; -; mRNA.
DR   RefSeq; NP_001003046.1; NM_001003046.1.
DR   AlphaFoldDB; Q9GMZ1; -.
DR   SMR; Q9GMZ1; -.
DR   STRING; 9612.ENSCAFP00000005489; -.
DR   PaxDb; Q9GMZ1; -.
DR   GeneID; 403574; -.
DR   KEGG; cfa:403574; -.
DR   CTD; 7350; -.
DR   eggNOG; KOG0753; Eukaryota.
DR   InParanoid; Q9GMZ1; -.
DR   OrthoDB; 984118at2759; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:1901612; F:cardiolipin binding; ISS:UniProtKB.
DR   GO; GO:0036041; F:long-chain fatty acid binding; ISS:UniProtKB.
DR   GO; GO:0017077; F:oxidative phosphorylation uncoupler activity; ISS:UniProtKB.
DR   GO; GO:0032555; F:purine ribonucleotide binding; ISS:UniProtKB.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:1990845; P:adaptive thermogenesis; ISS:UniProtKB.
DR   GO; GO:0071398; P:cellular response to fatty acid; ISS:UniProtKB.
DR   GO; GO:0032870; P:cellular response to hormone stimulus; ISS:UniProtKB.
DR   GO; GO:0034614; P:cellular response to reactive oxygen species; ISS:UniProtKB.
DR   GO; GO:1990542; P:mitochondrial transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0006839; P:mitochondrial transport; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; ISS:UniProtKB.
DR   GO; GO:1903426; P:regulation of reactive oxygen species biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0009409; P:response to cold; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; ISS:UniProtKB.
DR   GO; GO:0009266; P:response to temperature stimulus; ISS:UniProtKB.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002030; Mit_uncoupling_UCP-like.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   InterPro; IPR040011; UCP1.
DR   PANTHER; PTHR45618:SF19; PTHR45618:SF19; 1.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00784; MTUNCOUPLING.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Ion channel; Ion transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Oxidation; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..309
FT                   /note="Mitochondrial brown fat uncoupling protein 1"
FT                   /id="PRO_0000090655"
FT   TOPO_DOM        1..10
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:P04633"
FT   TRANSMEM        11..32
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        33..75
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:P04633"
FT   TRANSMEM        76..98
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..118
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:P04633"
FT   TRANSMEM        119..135
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..180
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:P04633"
FT   TRANSMEM        181..197
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        198..214
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:P04633"
FT   TRANSMEM        215..234
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        235..268
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:P04633"
FT   TRANSMEM        269..291
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..309
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:P04633"
FT   REPEAT          11..104
FT                   /note="Solcar 1"
FT   REPEAT          113..203
FT                   /note="Solcar 2"
FT   REPEAT          212..297
FT                   /note="Solcar 3"
FT   MOD_RES         256
FT                   /note="Cysteine sulfenic acid (-SOH)"
FT                   /evidence="ECO:0000250|UniProtKB:P12242"
SQ   SEQUENCE   309 AA;  33280 MW;  C4D33E2A3B08F16E CRC64;
     MLRAPGSDAP PTLSVRIAAA AGAACLADMI TFPLDTAKVR LQIQGEGQGQ PPRAPRYRGV
     LGTVATLART EGLQKLYSGL PAGLQRQVGF ASLRIGLYDS VREWLSPGQG AAASLGSRIS
     AGVMTGGAAV FIGQPTEVVK VRLQAQSHLH GRKPRYTGTY NAYRIIATTE GLTGLWKGTT
     PNLMRNVIIN CTELVTYDLM KEALVKNHLL ADDLPCHFLS ALVAGFCTTV LSSPVDVVKT
     RFVNSVPEQY TSVPNCAMTM LTKEGPLAFF KGFVPSFLRL GSWNVIMFVC FEQLKRELMK
     SGRTVDCAT
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024