UCP2_BOVIN
ID UCP2_BOVIN Reviewed; 309 AA.
AC Q3SZI5;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Mitochondrial uncoupling protein 2;
DE Short=UCP 2;
DE AltName: Full=Solute carrier family 25 member 8;
GN Name=UCP2; Synonyms=SLC25A8;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: UCP are mitochondrial transporter proteins that create proton
CC leaks across the inner mitochondrial membrane, thus uncoupling
CC oxidative phosphorylation from ATP synthesis. As a result, energy is
CC dissipated in the form of heat (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Acts as a dimer forming a proton channel. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; BC102839; AAI02840.1; -; mRNA.
DR RefSeq; NP_001028783.1; NM_001033611.2.
DR AlphaFoldDB; Q3SZI5; -.
DR STRING; 9913.ENSBTAP00000004810; -.
DR PaxDb; Q3SZI5; -.
DR Ensembl; ENSBTAT00000004810; ENSBTAP00000004810; ENSBTAG00000003692.
DR GeneID; 281562; -.
DR KEGG; bta:281562; -.
DR CTD; 7351; -.
DR VEuPathDB; HostDB:ENSBTAG00000003692; -.
DR VGNC; VGNC:36641; UCP2.
DR eggNOG; KOG0753; Eukaryota.
DR GeneTree; ENSGT00940000159524; -.
DR HOGENOM; CLU_015166_14_2_1; -.
DR InParanoid; Q3SZI5; -.
DR OMA; MMAANHS; -.
DR OrthoDB; 1126848at2759; -.
DR TreeFam; TF323211; -.
DR Reactome; R-BTA-167826; The fatty acid cycling model.
DR Reactome; R-BTA-167827; The proton buffering model.
DR Proteomes; UP000009136; Chromosome 15.
DR Bgee; ENSBTAG00000003692; Expressed in lung and 107 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017077; F:oxidative phosphorylation uncoupler activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1990845; P:adaptive thermogenesis; IBA:GO_Central.
DR GO; GO:1990542; P:mitochondrial transmembrane transport; IBA:GO_Central.
DR GO; GO:0006839; P:mitochondrial transport; IEA:InterPro.
DR GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IEA:Ensembl.
DR GO; GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Ensembl.
DR GO; GO:0009409; P:response to cold; IBA:GO_Central.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002030; Mit_uncoupling_UCP-like.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00784; MTUNCOUPLING.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..309
FT /note="Mitochondrial uncoupling protein 2"
FT /id="PRO_0000282884"
FT TOPO_DOM 1..10
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..32
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..77
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..100
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..119
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..136
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..180
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..197
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..214
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..234
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..268
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..291
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..309
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT REPEAT 11..106
FT /note="Solcar 1"
FT REPEAT 114..203
FT /note="Solcar 2"
FT REPEAT 212..297
FT /note="Solcar 3"
FT REGION 276..298
FT /note="Purine nucleotide binding"
FT /evidence="ECO:0000250"
SQ SEQUENCE 309 AA; 33274 MW; 3D2ECDC4FFDD9F82 CRC64;
MVGFKATDVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGERQGP MQAAASAQYR
GVLGTILTMV RTEGPRSLYS GLVAGLQRQM SFASVRIGLY DSVKQFYTKG SEHAGIGSRL
LAGSTTGALA VAVAQPTDVV KVRFQAQARA GAGRRYQSTV EAYKTIAREE GFRGLWKGTS
PNVARNAIVN CAELVTYDLI KDTLLKAHLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT
RYMNSALGQY SSAGHCALTM LQKEGPQAFY KGFMPSFLRL GSWNVVMFVT YEQLKRALMA
ARASREAPF
