ID   UCP2_CANLF              Reviewed;         309 AA.
AC   Q9N2J1; Q9TTT0;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Mitochondrial uncoupling protein 2;
DE            Short=UCP 2;
DE   AltName: Full=Solute carrier family 25 member 8;
GN   Name=UCP2; Synonyms=SLC25A8;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Beagle;
RX   PubMed=11959030; DOI=10.1016/s1096-4959(02)00004-0;
RA   Ishioka K., Kanehira K., Sasaki N., Kitamura H., Kimura K., Saito M.;
RT   "Canine mitochondrial uncoupling proteins: structure and mRNA expression of
RT   three isoforms in adult beagles.";
RL   Comp. Biochem. Physiol. 131B:483-489(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 4-197.
RA   Thompson G.M., Kelly L.J., Candelore M.R.;
RL   Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: UCP are mitochondrial transporter proteins that create proton
CC       leaks across the inner mitochondrial membrane, thus uncoupling
CC       oxidative phosphorylation from ATP synthesis. As a result, energy is
CC       dissipated in the form of heat (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Acts as a dimer forming a proton channel. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; AB020887; BAA90457.1; -; mRNA.
DR   EMBL; AF201377; AAF08309.1; -; mRNA.
DR   RefSeq; NP_001003048.1; NM_001003048.1.
DR   AlphaFoldDB; Q9N2J1; -.
DR   SMR; Q9N2J1; -.
DR   STRING; 9615.ENSCAFP00000008312; -.
DR   PaxDb; Q9N2J1; -.
DR   GeneID; 403576; -.
DR   KEGG; cfa:403576; -.
DR   CTD; 7351; -.
DR   eggNOG; KOG0753; Eukaryota.
DR   InParanoid; Q9N2J1; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006839; P:mitochondrial transport; IEA:InterPro.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002030; Mit_uncoupling_UCP-like.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00784; MTUNCOUPLING.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..309
FT                   /note="Mitochondrial uncoupling protein 2"
FT                   /id="PRO_0000090663"
FT   TOPO_DOM        1..10
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..32
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        33..77
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..100
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        101..119
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..136
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        137..180
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..197
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        198..214
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..234
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        235..268
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..291
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..309
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   REPEAT          11..106
FT                   /note="Solcar 1"
FT   REPEAT          114..203
FT                   /note="Solcar 2"
FT   REPEAT          212..297
FT                   /note="Solcar 3"
FT   REGION          276..298
FT                   /note="Purine nucleotide binding"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        64
FT                   /note="C -> G (in Ref. 2; AAF08309)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   309 AA;  33270 MW;  D9860F0EA8B870BF CRC64;
     MVGFKATDVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGERQGP VRAAASAQYR
     GVLCTILTMV RTEGPRSLYS GLVAGLQRQM SFASVRIGLY DSVKQFYTKG SEHAGIGSRL
     LAGSTTGALA VAVAQPTDVV KVRFQAQARA GSGRRYQSTV DAYKTIAREE GFRGLWKGTS
     PNVARNAIVN CAELVTYDLI KDALLKANLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT
     RYMNSALGQY SSAGHCALTM LQKEGPRAFY KGFMPSFLRL GSWNVVMFVT YEQLKRALMA
     ACTSREAPF