ID   UCP2_CYPCA              Reviewed;         310 AA.
AC   Q9W725;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Mitochondrial uncoupling protein 2;
DE            Short=UCP 2;
DE   AltName: Full=Solute carrier family 25 member 8;
GN   Name=ucp2; Synonyms=slc25a8;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Stuart J.A., Harper J.A., Brindle K.M., Brand M.D.;
RT   "Uncoupling protein 1 homologues and thermogenesis? UCP2 from cold-blooded
RT   vertebrates.";
RL   Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: UCP are mitochondrial transporter proteins that create proton
CC       leaks across the inner mitochondrial membrane, thus uncoupling
CC       oxidative phosphorylation from ATP synthesis. As a result, energy is
CC       dissipated in the form of heat (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Acts as a dimer forming a proton channel. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; AJ243486; CAB46248.1; -; mRNA.
DR   AlphaFoldDB; Q9W725; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006839; P:mitochondrial transport; IEA:InterPro.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002030; Mit_uncoupling_UCP-like.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00784; MTUNCOUPLING.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..310
FT                   /note="Mitochondrial uncoupling protein 2"
FT                   /id="PRO_0000090669"
FT   TOPO_DOM        1..10
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..32
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        33..78
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..101
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..120
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..137
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        138..181
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..198
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        199..215
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..235
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        236..269
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..292
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..310
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   REPEAT          11..107
FT                   /note="Solcar 1"
FT   REPEAT          115..204
FT                   /note="Solcar 2"
FT   REPEAT          213..298
FT                   /note="Solcar 3"
FT   REGION          277..299
FT                   /note="Purine nucleotide binding"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   310 AA;  33532 MW;  AD0E4D733C73704E CRC64;
     MVGFRAGDVP PTATVKFIGA GTAACIADLF TFPLDTAKVR LQIQGESKIP VNTGHGPVKY
     RGVFGTISTM VRVEGPRSLY SGLVAGLQRQ MSFASVRIGL YDSVKQFYTK GSEHVGIGSR
     LMAGCTTGAM AVALAQPTDV VKVRFQAQNS AGANKRYHGT MDAYRTIAKE EGFRGLWKGT
     GPNITRNAIV NCTELVTYDL IKDALLKSSL MTDDLPCHFT SAFGAGFCTT VIASPVDVVK
     TRYMNSAPGQ YCSALNCAVA MLTKEGPKAF YKGFMPSFLR LGSWNVVMFV TYEQLKRAMM
     AARHNWATPL