UCP2_PIG
ID UCP2_PIG Reviewed; 309 AA.
AC O97562; Q19B01; Q5XQS5; Q9GK29;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Mitochondrial uncoupling protein 2;
DE Short=UCP 2;
DE AltName: Full=Solute carrier family 25 member 8;
GN Name=UCP2; Synonyms=SLC25A8;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=White adipose tissue;
RA Werner P., Nowaczyk K., Neuenschwander S., Strazinger G.;
RT "Characterization of the porcine uncoupling proteins 2 and 3 (UCP2 and 3)
RT and their localization to chromosome 9p by somatic cell hybrids.";
RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Zhao X.-B., Li H.J., Li Y.H.;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Zhao X.-B., Li H.J.;
RT "Cloning pig uncoupling protein 2 and 3 genes.";
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: UCP are mitochondrial transporter proteins that create proton
CC leaks across the inner mitochondrial membrane, thus uncoupling
CC oxidative phosphorylation from ATP synthesis. As a result, energy is
CC dissipated in the form of heat (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Acts as a dimer forming a proton channel. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AF036757; AAD05201.1; -; mRNA.
DR EMBL; AY739703; AAU94639.1; -; Genomic_DNA.
DR EMBL; DQ530365; ABF74757.1; -; mRNA.
DR EMBL; DQ530367; ABF74759.1; -; mRNA.
DR RefSeq; NP_999454.1; NM_214289.1.
DR RefSeq; XP_005667155.1; XM_005667098.2.
DR AlphaFoldDB; O97562; -.
DR STRING; 9823.ENSSSCP00000015752; -.
DR PaxDb; O97562; -.
DR PeptideAtlas; O97562; -.
DR PRIDE; O97562; -.
DR Ensembl; ENSSSCT00005008730; ENSSSCP00005005152; ENSSSCG00005005732.
DR Ensembl; ENSSSCT00070037407; ENSSSCP00070031279; ENSSSCG00070018943.
DR GeneID; 397549; -.
DR KEGG; ssc:397549; -.
DR CTD; 7351; -.
DR eggNOG; KOG0753; Eukaryota.
DR HOGENOM; CLU_015166_14_2_1; -.
DR InParanoid; O97562; -.
DR OrthoDB; 1126848at2759; -.
DR TreeFam; TF323211; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Chromosome 9.
DR Genevisible; O97562; SS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017077; F:oxidative phosphorylation uncoupler activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1990845; P:adaptive thermogenesis; IBA:GO_Central.
DR GO; GO:1990542; P:mitochondrial transmembrane transport; IBA:GO_Central.
DR GO; GO:0006839; P:mitochondrial transport; IEA:InterPro.
DR GO; GO:0009409; P:response to cold; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002030; Mit_uncoupling_UCP-like.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00784; MTUNCOUPLING.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..309
FT /note="Mitochondrial uncoupling protein 2"
FT /id="PRO_0000090666"
FT TOPO_DOM 1..10
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..32
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..77
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..100
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..119
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..136
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..180
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..197
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..214
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..234
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..268
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..291
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..309
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT REPEAT 11..106
FT /note="Solcar 1"
FT REPEAT 114..203
FT /note="Solcar 2"
FT REPEAT 212..297
FT /note="Solcar 3"
FT REGION 276..298
FT /note="Purine nucleotide binding"
FT /evidence="ECO:0000250"
SQ SEQUENCE 309 AA; 33259 MW; 7A67D59946DA21BD CRC64;
MVGFKATEVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGERRGP VQAAASAQYR
GVLGTILTMV RNEGPRSLYN GLVAGLQRQM SFASVRIGLY DSVKHFYTKG SEHAGIGSRL
LAGSTTGALA VAVAQPTDVV KVRFQAQARA GGGRRYRSTV DAYKTIAREE GLRGLWKGTS
PNVARNAIVN CAELVTYDLI KDTLLKADLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT
RYMNSAPGQY SSAGHCALTM LQKEGPRAFY KGFTPSFLRL GSWNVVMFVT YEQLKRALMA
ARASREAPF
