ID   UCP3_BOVIN              Reviewed;         311 AA.
AC   O77792; Q9TVA1;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Mitochondrial uncoupling protein 3;
DE            Short=UCP 3;
DE   AltName: Full=Solute carrier family 25 member 9;
GN   Name=UCP3; Synonyms=SLC25A9;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-274, AND
RP   VARIANT THR-53.
RC   TISSUE=Muscle;
RX   PubMed=10582284; DOI=10.1046/j.1365-2052.1999.00506.x;
RA   Stone R.T., Rexroad C.E. III, Smith T.P.L.;
RT   "Bovine UCP2 and UCP3 map to BTA15.";
RL   Anim. Genet. 30:378-381(1999).
CC   -!- FUNCTION: UCP are mitochondrial transporter proteins that create proton
CC       leaks across the inner mitochondrial membrane, thus uncoupling
CC       oxidative phosphorylation. As a result, energy is dissipated in the
CC       form of heat. May play a role in the modulation of tissue respiratory
CC       control. Participates in thermogenesis and energy balance (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; AF092048; AAC61762.1; -; mRNA.
DR   EMBL; AF127030; AAD33339.1; -; Genomic_DNA.
DR   RefSeq; NP_776635.1; NM_174210.1.
DR   AlphaFoldDB; O77792; -.
DR   STRING; 9913.ENSBTAP00000006918; -.
DR   PaxDb; O77792; -.
DR   Ensembl; ENSBTAT00000006918; ENSBTAP00000006918; ENSBTAG00000005259.
DR   GeneID; 281563; -.
DR   KEGG; bta:281563; -.
DR   CTD; 7352; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005259; -.
DR   VGNC; VGNC:36642; UCP3.
DR   eggNOG; KOG0753; Eukaryota.
DR   GeneTree; ENSGT00940000161030; -.
DR   InParanoid; O77792; -.
DR   OMA; DCMLKLV; -.
DR   OrthoDB; 1126848at2759; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000005259; Expressed in infraspinatus muscle and 43 other tissues.
DR   ExpressionAtlas; O77792; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017077; F:oxidative phosphorylation uncoupler activity; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:1990845; P:adaptive thermogenesis; IBA:GO_Central.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
DR   GO; GO:1990542; P:mitochondrial transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006839; P:mitochondrial transport; IEA:InterPro.
DR   GO; GO:0009409; P:response to cold; IBA:GO_Central.
DR   GO; GO:0000303; P:response to superoxide; IEA:Ensembl.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002030; Mit_uncoupling_UCP-like.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00784; MTUNCOUPLING.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..311
FT                   /note="Mitochondrial uncoupling protein 3"
FT                   /id="PRO_0000090670"
FT   TRANSMEM        11..32
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..99
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..136
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..199
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..236
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..293
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          11..105
FT                   /note="Solcar 1"
FT   REPEAT          114..205
FT                   /note="Solcar 2"
FT   REPEAT          214..299
FT                   /note="Solcar 3"
FT   REGION          278..300
FT                   /note="Purine nucleotide binding"
FT                   /evidence="ECO:0000250"
FT   VARIANT         53
FT                   /note="A -> T"
FT                   /evidence="ECO:0000269|PubMed:10582284"
SQ   SEQUENCE   311 AA;  34206 MW;  B1A1D26E25650D04 CRC64;
     MVGLQPSERP PTTSVKFLAA GTAACFADLL TFPLDTAKVR LQIQGENQAA LAARSAQYRG
     VLGTILTMVR TEGPRSLYSG LVAGLQRQMS FASIRIGLYD SVKQFYTPKG SDHSSIITRI
     LAGCTTGAMA VTCAQPTDVV KIRFQASMHT GLGGNRKYSG TMDAYRTIAR EEGVRGLWKG
     ILPNITRNAI VNCGEMVTYD IIKEKLLDYH LLTDNFPCHF VSAFGAGFCA TLVASPVDVV
     KTRYMNSPPG QYHSPFDCML KMVTQEGPTA FYKGFTPSFL RLGSWNVVMF VTYEQMKRAL
     MKVQMLRDSP F