ID   UCP3_CANLF              Reviewed;         311 AA.
AC   Q9N2I9; Q9TTS9;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Mitochondrial uncoupling protein 3;
DE            Short=UCP 3;
DE   AltName: Full=Solute carrier family 25 member 9;
GN   Name=UCP3; Synonyms=SLC25A9;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Beagle;
RX   PubMed=11959030; DOI=10.1016/s1096-4959(02)00004-0;
RA   Ishioka K., Kanehira K., Sasaki N., Kitamura H., Kimura K., Saito M.;
RT   "Canine mitochondrial uncoupling proteins: structure and mRNA expression of
RT   three isoforms in adult beagles.";
RL   Comp. Biochem. Physiol. 131B:483-489(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 14-146.
RA   Thompson G.M., Kelly L.J., Candelore M.R.;
RL   Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: UCP are mitochondrial transporter proteins that create proton
CC       leaks across the inner mitochondrial membrane, thus uncoupling
CC       oxidative phosphorylation. As a result, energy is dissipated in the
CC       form of heat. May play a role in the modulation of tissue respiratory
CC       control. Participates in thermogenesis and energy balance (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB022020; BAA90458.1; -; mRNA.
DR   EMBL; AF201378; AAF08310.1; -; mRNA.
DR   RefSeq; NP_001003047.1; NM_001003047.1.
DR   AlphaFoldDB; Q9N2I9; -.
DR   STRING; 9615.ENSCAFP00000008310; -.
DR   GeneID; 403575; -.
DR   KEGG; cfa:403575; -.
DR   CTD; 7352; -.
DR   InParanoid; Q9N2I9; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017077; F:oxidative phosphorylation uncoupler activity; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:1990845; P:adaptive thermogenesis; IBA:GO_Central.
DR   GO; GO:1990542; P:mitochondrial transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006839; P:mitochondrial transport; IEA:InterPro.
DR   GO; GO:0009409; P:response to cold; IBA:GO_Central.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002030; Mit_uncoupling_UCP-like.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00784; MTUNCOUPLING.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..311
FT                   /note="Mitochondrial uncoupling protein 3"
FT                   /id="PRO_0000090671"
FT   TRANSMEM        11..32
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..99
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..136
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..199
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..236
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..293
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          11..105
FT                   /note="Solcar 1"
FT   REPEAT          114..205
FT                   /note="Solcar 2"
FT   REPEAT          214..299
FT                   /note="Solcar 3"
FT   REGION          278..300
FT                   /note="Purine nucleotide binding"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        14
FT                   /note="A -> G (in Ref. 2; AAF08310)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   311 AA;  34138 MW;  A719FB8D66637502 CRC64;
     MVGLKPSEVP PTTAVKFLGA GTAACFADLL TFPLDTAKVR LQIQGENQAT QAARRIQYRG
     VLGTILTMVR TEGPRSPYNG LVAGLQRQMS FASIRIGLYD SVKQFYTPKG SDHSSITTRI
     LAGCTTGAMA VSCAQPTDVV KVRFQASIHL GAGSNRKYSG TMDAYRTIAR EEGVRGLWKG
     TLPNITRNAI VNCAEMVTYD IIKEKLLDYH LLTDNFPCHL ISAFGAGFCA TVVASPVDVV
     KTRYMNSPPG QYCSPLDCML KMVTQEGPTA FYKGFTPSFL RLGTWNVVMF VTYEQLKRAL
     MKVQMLRESP F