UCP3_MOUSE
ID UCP3_MOUSE Reviewed; 308 AA.
AC P56501; O88293;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Mitochondrial uncoupling protein 3;
DE Short=UCP 3;
DE AltName: Full=Solute carrier family 25 member 9;
GN Name=Ucp3; Synonyms=Slc25a9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RA Sanchis D., Fleury C., Bouillaud F., Ricquier D.;
RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Swiss Webster; TISSUE=Embryo;
RX PubMed=9666083; DOI=10.1016/s0378-1119(98)00279-0;
RA Yoshitomi H., Yamazaki K., Tanaka I.;
RT "Cloning of mouse uncoupling protein 3 cDNA and 5'-flanking region, and its
RT genetic map.";
RL Gene 215:77-84(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Skeletal muscle;
RA Grujic D., Zhan C.-Y., Sleiker L.J., Lowell B.B.;
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Skeletal muscle;
RA Son C., Hosoda K., Matsuda J., Nakao K.;
RT "Cloning of mouse UCP3 cDNA.";
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10066417; DOI=10.1006/bbrc.1999.0239;
RA Gong D.W., He Y., Reitman M.L.;
RT "Genomic organization and regulation by dietary fat of the uncoupling
RT protein 3 and 2 genes.";
RL Biochem. Biophys. Res. Commun. 256:27-32(1999).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 84-180.
RC STRAIN=C57BL/6J; TISSUE=Skeletal muscle;
RX PubMed=9600108; DOI=10.1006/bbrc.1998.8600;
RA Shimokawa T., Kato M., Ezaki O., Hashimoto S.;
RT "Transcriptional regulation of muscle-specific genes during myoblast
RT differentiation.";
RL Biochem. Biophys. Res. Commun. 246:287-292(1998).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 162-252.
RA Yan X., Ramsay T.G.;
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, and Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: UCP are mitochondrial transporter proteins that create proton
CC leaks across the inner mitochondrial membrane, thus uncoupling
CC oxidative phosphorylation. As a result, energy is dissipated in the
CC form of heat. May play a role in the modulation of tissue respiratory
CC control. Participates in thermogenesis and energy balance (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AF032902; AAB87084.1; -; mRNA.
DR EMBL; AB010742; BAA25697.1; -; mRNA.
DR EMBL; AF030164; AAD01892.1; -; mRNA.
DR EMBL; AB008216; BAA33502.1; -; mRNA.
DR EMBL; AF053352; AAC28328.1; -; mRNA.
DR EMBL; AB013132; BAA31989.1; -; mRNA.
DR EMBL; AF019883; AAB71543.1; -; mRNA.
DR CCDS; CCDS21497.1; -.
DR RefSeq; NP_033490.1; NM_009464.3.
DR AlphaFoldDB; P56501; -.
DR CORUM; P56501; -.
DR STRING; 10090.ENSMUSP00000032958; -.
DR iPTMnet; P56501; -.
DR PhosphoSitePlus; P56501; -.
DR MaxQB; P56501; -.
DR PaxDb; P56501; -.
DR PRIDE; P56501; -.
DR ProteomicsDB; 298428; -.
DR Antibodypedia; 4388; 285 antibodies from 33 providers.
DR DNASU; 22229; -.
DR Ensembl; ENSMUST00000032958; ENSMUSP00000032958; ENSMUSG00000032942.
DR Ensembl; ENSMUST00000107059; ENSMUSP00000102674; ENSMUSG00000032942.
DR GeneID; 22229; -.
DR KEGG; mmu:22229; -.
DR UCSC; uc009ina.1; mouse.
DR CTD; 7352; -.
DR MGI; MGI:1099787; Ucp3.
DR VEuPathDB; HostDB:ENSMUSG00000032942; -.
DR eggNOG; KOG0753; Eukaryota.
DR GeneTree; ENSGT00940000161030; -.
DR HOGENOM; CLU_015166_14_2_1; -.
DR InParanoid; P56501; -.
DR OMA; DCMLKLV; -.
DR OrthoDB; 984118at2759; -.
DR PhylomeDB; P56501; -.
DR TreeFam; TF323211; -.
DR Reactome; R-MMU-167826; The fatty acid cycling model.
DR Reactome; R-MMU-167827; The proton buffering model.
DR BioGRID-ORCS; 22229; 5 hits in 73 CRISPR screens.
DR ChiTaRS; Ucp3; mouse.
DR PRO; PR:P56501; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P56501; protein.
DR Bgee; ENSMUSG00000032942; Expressed in hindlimb stylopod muscle and 92 other tissues.
DR ExpressionAtlas; P56501; baseline and differential.
DR Genevisible; P56501; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IMP:MGI.
DR GO; GO:0017077; F:oxidative phosphorylation uncoupler activity; IMP:MGI.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1990845; P:adaptive thermogenesis; IBA:GO_Central.
DR GO; GO:0007568; P:aging; IEA:Ensembl.
DR GO; GO:0032870; P:cellular response to hormone stimulus; IEA:Ensembl.
DR GO; GO:0006631; P:fatty acid metabolic process; IMP:MGI.
DR GO; GO:1990542; P:mitochondrial transmembrane transport; IBA:GO_Central.
DR GO; GO:0006839; P:mitochondrial transport; IEA:InterPro.
DR GO; GO:0014823; P:response to activity; IEA:Ensembl.
DR GO; GO:0009409; P:response to cold; IBA:GO_Central.
DR GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; ISO:MGI.
DR GO; GO:0032868; P:response to insulin; IEA:Ensembl.
DR GO; GO:0007584; P:response to nutrient; IEA:Ensembl.
DR GO; GO:0000303; P:response to superoxide; IMP:MGI.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002030; Mit_uncoupling_UCP-like.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00784; MTUNCOUPLING.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..308
FT /note="Mitochondrial uncoupling protein 3"
FT /id="PRO_0000090673"
FT TRANSMEM 11..32
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..196
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..233
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..290
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 11..102
FT /note="Solcar 1"
FT REPEAT 111..202
FT /note="Solcar 2"
FT REPEAT 211..296
FT /note="Solcar 3"
FT REGION 275..297
FT /note="Purine nucleotide binding"
FT /evidence="ECO:0000250"
FT CONFLICT 179
FT /note="W -> L (in Ref. 6; BAA31989)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 308 AA; 33911 MW; 12CAD7674DF7D0C3 CRC64;
MVGLQPSEVP PTTVVKFLGA GTAACFADLL TFPLDTAKVR LQIQGENPGA QSVQYRGVLG
TILTMVRTEG PRSPYSGLVA GLHRQMSFAS IRIGLYDSVK QFYTPKGADH SSVAIRILAG
CTTGAMAVTC AQPTDVVKVR FQAMIRLGTG GERKYRGTMD AYRTIAREEG VRGLWKGTWP
NITRNAIVNC AEMVTYDIIK EKLLESHLFT DNFPCHFVSA FGAGFCATVV ASPVDVVKTR
YMNAPLGRYR SPLHCMLKMV AQEGPTAFYK GFVPSFLRLG AWNVMMFVTY EQLKRALMKV
QVLRESPF
