ID   UCP3_PIG                Reviewed;         308 AA.
AC   O97649; Q19B00; Q9XSE6;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Mitochondrial uncoupling protein 3;
DE            Short=UCP 3;
DE   AltName: Full=Solute carrier family 25 member 9;
GN   Name=UCP3; Synonyms=SLC25A9;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=White adipose tissue;
RA   Werner P., Nowaczyk K., Neuenschwander S., Strazinger G.;
RT   "Characterization of the porcine uncoupling proteins 2 and 3 (UCP2 and 3)
RT   and their localization to chromosome 9p by somatic cell hybrids.";
RL   Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Large white X Pietrain; TISSUE=Skeletal muscle;
RA   Damon M., Vincent A., Herpin P.;
RT   "First evidence of uncoupling protein (UCP) gene expression in piglet
RT   skeletal muscle.";
RL   Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Zhao X.B., Li H.J.;
RT   "Cloning pig uncoupling protein 2 and 3 genes.";
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: UCP are mitochondrial transporter proteins that create proton
CC       leaks across the inner mitochondrial membrane, thus uncoupling
CC       oxidative phosphorylation. As a result, energy is dissipated in the
CC       form of heat. May play a role in the modulation of tissue respiratory
CC       control. Participates in thermogenesis and energy balance (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; AF095744; AAD08811.1; -; mRNA.
DR   EMBL; AF128837; AAD33396.1; -; mRNA.
DR   EMBL; DQ530368; ABF74760.1; -; mRNA.
DR   RefSeq; NP_999214.1; NM_214049.1.
DR   AlphaFoldDB; O97649; -.
DR   SMR; O97649; -.
DR   STRING; 9823.ENSSSCP00000015753; -.
DR   PaxDb; O97649; -.
DR   GeneID; 397116; -.
DR   KEGG; ssc:397116; -.
DR   CTD; 7352; -.
DR   eggNOG; KOG0753; Eukaryota.
DR   InParanoid; O97649; -.
DR   OrthoDB; 984118at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006839; P:mitochondrial transport; IEA:InterPro.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002030; Mit_uncoupling_UCP-like.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00784; MTUNCOUPLING.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..308
FT                   /note="Mitochondrial uncoupling protein 3"
FT                   /id="PRO_0000090674"
FT   TRANSMEM        11..32
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..96
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..133
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..196
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..233
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..290
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          11..102
FT                   /note="Solcar 1"
FT   REPEAT          111..202
FT                   /note="Solcar 2"
FT   REPEAT          211..296
FT                   /note="Solcar 3"
FT   REGION          275..297
FT                   /note="Purine nucleotide binding"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        7..8
FT                   /note="PE -> SD (in Ref. 2; AAD33396)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13
FT                   /note="T -> M (in Ref. 2; AAD33396)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        17
FT                   /note="L -> F (in Ref. 2; AAD33396)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        49
FT                   /note="A -> AVQT (in Ref. 2; AAD33396)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        150
FT                   /note="R -> G (in Ref. 2; AAD33396)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   308 AA;  33772 MW;  FDF1F2BC28FDE997 CRC64;
     MVGLKPPEVP PTTAVKLLGA GTAACFADLL TFPLDTAKVR LQIQGENQAA RSAQYRGVLG
     TILTMVRNEG PRSPYNGLVA GLQRQMSFAS IRIGLYDSVK QLYTPKGSDH SSITTRILAG
     CTTGAMAVTC AQPTDVVKVR FQASIHAGPR SNRKYSGTMD AYRTIAREEG VRGLWKGILP
     NITRNAIVNC AEMVTYDVIK EKVLDYHLLT DNLPCHFVSA FGAGFCATVV ASPVDVVKTR
     YMNSPPGQYQ NPLDCMLKMV TQEGPTAFYK GFTPSFLRLG SWNVVMFVSY EQLKRALMKV
     QMLRESPF