UCP3_RAT
ID UCP3_RAT Reviewed; 308 AA.
AC P56499;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Mitochondrial uncoupling protein 3;
DE Short=UCP 3;
DE AltName: Full=Solute carrier family 25 member 9;
GN Name=Ucp3; Synonyms=Slc25a9;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Skeletal muscle;
RX PubMed=9414126; DOI=10.1016/s0014-5793(97)01381-1;
RA Matsuda J., Hosoda K., Itoh H., Son C., Doi K., Tanaka T., Fukunaga Y.,
RA Inoue G., Nishimura H., Yoshimasa Y., Yamori Y., Nakao K.;
RT "Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: their
RT gene expression in rats fed high-fat diet.";
RL FEBS Lett. 418:200-204(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar; TISSUE=Skeletal muscle;
RX PubMed=9506477; DOI=10.1096/fasebj.12.3.335;
RA Boss O., Samec S., Desplanches D., Mayet M.-H., Seydoux J., Muzzin P.,
RA Giacobino J.-P.;
RT "Effect of endurance training on mRNA expression of uncoupling proteins 1,
RT 2, and 3 in the rat.";
RL FASEB J. 12:335-339(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Skeletal muscle;
RX PubMed=9725803; DOI=10.1152/ajpendo.1998.275.3.e386;
RA Lin B.-Z., Coughlin S., Pilch P.F.;
RT "Bidirectional regulation of uncoupling protein-3 and GLUT-4 mRNA in
RT skeletal muscle by cold.";
RL Am. J. Physiol. 275:E386-E391(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Skeletal muscle;
RA Solanes G., Valet P., Lowell B.B.;
RT "Lipopolysaccharide treatment increases thermogenesis and induces
RT uncoupling protein-3 gene expression in skeletal muscle.";
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: UCP are mitochondrial transporter proteins that create proton
CC leaks across the inner mitochondrial membrane, thus uncoupling
CC oxidative phosphorylation. As a result, energy is dissipated in the
CC form of heat. May play a role in the modulation of tissue respiratory
CC control. Participates in thermogenesis and energy balance (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AB006614; BAA23355.1; -; mRNA.
DR EMBL; U92069; AAB71523.1; -; mRNA.
DR EMBL; AF035943; AAC05740.1; -; mRNA.
DR EMBL; AF030163; AAD01891.1; -; mRNA.
DR EMBL; BC072546; AAH72546.1; -; mRNA.
DR RefSeq; NP_037299.1; NM_013167.2.
DR AlphaFoldDB; P56499; -.
DR STRING; 10116.ENSRNOP00000024005; -.
DR PaxDb; P56499; -.
DR Ensembl; ENSRNOT00000024005; ENSRNOP00000024005; ENSRNOG00000017716.
DR GeneID; 25708; -.
DR KEGG; rno:25708; -.
DR UCSC; RGD:3933; rat.
DR CTD; 7352; -.
DR RGD; 3933; Ucp3.
DR eggNOG; KOG0753; Eukaryota.
DR GeneTree; ENSGT00940000161030; -.
DR HOGENOM; CLU_015166_14_2_1; -.
DR InParanoid; P56499; -.
DR OMA; DCMLKLV; -.
DR OrthoDB; 984118at2759; -.
DR PhylomeDB; P56499; -.
DR TreeFam; TF323211; -.
DR Reactome; R-RNO-167826; The fatty acid cycling model.
DR Reactome; R-RNO-167827; The proton buffering model.
DR PRO; PR:P56499; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000017716; Expressed in skeletal muscle tissue and 11 other tissues.
DR Genevisible; P56499; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IDA:RGD.
DR GO; GO:0017077; F:oxidative phosphorylation uncoupler activity; ISO:RGD.
DR GO; GO:0015078; F:proton transmembrane transporter activity; TAS:RGD.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1990845; P:adaptive thermogenesis; IBA:GO_Central.
DR GO; GO:0007568; P:aging; IEP:RGD.
DR GO; GO:0032870; P:cellular response to hormone stimulus; IEP:RGD.
DR GO; GO:0006631; P:fatty acid metabolic process; ISO:RGD.
DR GO; GO:1990542; P:mitochondrial transmembrane transport; IBA:GO_Central.
DR GO; GO:0006839; P:mitochondrial transport; IEA:InterPro.
DR GO; GO:0014823; P:response to activity; IEP:RGD.
DR GO; GO:0009409; P:response to cold; IEP:RGD.
DR GO; GO:0051384; P:response to glucocorticoid; IEP:RGD.
DR GO; GO:0001666; P:response to hypoxia; IDA:HGNC-UCL.
DR GO; GO:0032868; P:response to insulin; IEP:RGD.
DR GO; GO:0007584; P:response to nutrient; IEP:RGD.
DR GO; GO:0048545; P:response to steroid hormone; IEP:RGD.
DR GO; GO:0000303; P:response to superoxide; IDA:RGD.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002030; Mit_uncoupling_UCP-like.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00784; MTUNCOUPLING.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..308
FT /note="Mitochondrial uncoupling protein 3"
FT /id="PRO_0000090675"
FT TRANSMEM 11..32
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..196
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..233
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..290
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 11..102
FT /note="Solcar 1"
FT REPEAT 111..202
FT /note="Solcar 2"
FT REPEAT 211..296
FT /note="Solcar 3"
FT REGION 275..297
FT /note="Purine nucleotide binding"
FT /evidence="ECO:0000250"
SQ SEQUENCE 308 AA; 34015 MW; F86E784530ACC555 CRC64;
MVGLQPSEVP PTTVVKFLGA GTAACFADLL TFPLDTAKVR LQIQGENPGV QSVQYRGVLG
TILTMVRTEG PRSPYSGLVA GLHRQMSFAS IRIGLYDSVK QFYTPKGTDH SSVAIRILAG
CTTGAMAVTC AQPTDVVKVR FQAMIRLGTG GERKYRGTMD AYRTIAREEG VRGLWKGTWP
NITRNAIVNC AEMVTYDIIK EKLLDSHLFT DNFPCHFVSA FGAGFCATVV ASPVDVVKTR
YMNAPPGRYR SPLHCMLRMV AQEGPTAFYK GFMPSFLRLG SWNVMMFVTY EQLKRALMKV
QVLRESPF
