UCP5_HUMAN
ID UCP5_HUMAN Reviewed; 325 AA.
AC O95258; D3DTG2; Q0VDH7; Q9HC60; Q9HC61;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 183.
DE RecName: Full=Brain mitochondrial carrier protein 1;
DE Short=BMCP-1;
DE AltName: Full=Mitochondrial uncoupling protein 5;
DE Short=UCP 5;
DE AltName: Full=Solute carrier family 25 member 14;
GN Name=SLC25A14; Synonyms=BMCP1, UCP5; ORFNames=UNQ791/PRO1682;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=9852133; DOI=10.1074/jbc.273.51.34611;
RA Sanchis D., Fleury C., Chomiki N., Goubern M., Huang Q., Neverova M.,
RA Gregoire F., Easlick J., Raimbault S., Levi-Meyrueis C., Miroux B.,
RA Collins S., Seldin M., Richard D., Warden C., Bouillaud F., Ricquier D.;
RT "BMCP1, a novel mitochondrial carrier with high expression in the central
RT nervous system of humans and rodents, and respiration uncoupling activity
RT in recombinant yeast.";
RL J. Biol. Chem. 273:34611-34615(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, AND TISSUE SPECIFICITY.
RX PubMed=10928996; DOI=10.1096/fj.99-0834com;
RA Yu X.X., Mao W., Zhong A., Schow P., Brush J., Sherwood S.W., Adams S.H.,
RA Pan G.;
RT "Characterization of novel UCP5/BMCP1 isoforms and differential regulation
RT of UCP4 and UCP5 expression through dietary or temperature manipulation.";
RL FASEB J. 14:1611-1618(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Participates in the mitochondrial proton leak measured in
CC brain mitochondria.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=UCP5L;
CC IsoId=O95258-1; Sequence=Displayed;
CC Name=2; Synonyms=UCP5S;
CC IsoId=O95258-2; Sequence=VSP_003272;
CC Name=3; Synonyms=UCP5SI;
CC IsoId=O95258-3; Sequence=VSP_003272, VSP_003273;
CC -!- TISSUE SPECIFICITY: Mainly expressed in brain. Some expression in
CC testis and pituitary. {ECO:0000269|PubMed:10928996}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AF078544; AAD04346.1; -; mRNA.
DR EMBL; AF155809; AAG29582.1; -; mRNA.
DR EMBL; AF155810; AAG29583.1; -; mRNA.
DR EMBL; AF155811; AAG29584.1; -; mRNA.
DR EMBL; AY358099; AAQ88466.1; -; mRNA.
DR EMBL; AL035423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471107; EAX11804.1; -; Genomic_DNA.
DR EMBL; BC119666; AAI19667.1; -; mRNA.
DR EMBL; BC119667; AAI19668.1; -; mRNA.
DR CCDS; CCDS14623.1; -. [O95258-1]
DR CCDS; CCDS14624.1; -. [O95258-2]
DR CCDS; CCDS76020.1; -. [O95258-3]
DR RefSeq; NP_001269124.1; NM_001282195.1. [O95258-1]
DR RefSeq; NP_001269125.1; NM_001282196.1. [O95258-2]
DR RefSeq; NP_001269126.1; NM_001282197.1. [O95258-3]
DR RefSeq; NP_001269127.1; NM_001282198.1.
DR AlphaFoldDB; O95258; -.
DR BioGRID; 114485; 30.
DR IntAct; O95258; 7.
DR STRING; 9606.ENSP00000477981; -.
DR TCDB; 2.A.29.24.1; the mitochondrial carrier (mc) family.
DR iPTMnet; O95258; -.
DR PhosphoSitePlus; O95258; -.
DR BioMuta; SLC25A14; -.
DR EPD; O95258; -.
DR jPOST; O95258; -.
DR MassIVE; O95258; -.
DR MaxQB; O95258; -.
DR PaxDb; O95258; -.
DR PeptideAtlas; O95258; -.
DR PRIDE; O95258; -.
DR ProteomicsDB; 50752; -. [O95258-1]
DR ProteomicsDB; 50753; -. [O95258-2]
DR ProteomicsDB; 50754; -. [O95258-3]
DR Antibodypedia; 16263; 95 antibodies from 26 providers.
DR DNASU; 9016; -.
DR Ensembl; ENST00000218197.9; ENSP00000218197.5; ENSG00000102078.16. [O95258-1]
DR Ensembl; ENST00000339231.3; ENSP00000342797.3; ENSG00000102078.16. [O95258-3]
DR Ensembl; ENST00000361980.9; ENSP00000354455.5; ENSG00000102078.16. [O95258-2]
DR Ensembl; ENST00000545805.6; ENSP00000444642.2; ENSG00000102078.16. [O95258-1]
DR Ensembl; ENST00000612248.4; ENSP00000477981.1; ENSG00000102078.16. [O95258-3]
DR GeneID; 9016; -.
DR KEGG; hsa:9016; -.
DR MANE-Select; ENST00000545805.6; ENSP00000444642.2; NM_001282195.2; NP_001269124.1.
DR UCSC; uc004evp.3; human. [O95258-1]
DR CTD; 9016; -.
DR DisGeNET; 9016; -.
DR GeneCards; SLC25A14; -.
DR HGNC; HGNC:10984; SLC25A14.
DR HPA; ENSG00000102078; Low tissue specificity.
DR MIM; 300242; gene.
DR neXtProt; NX_O95258; -.
DR OpenTargets; ENSG00000102078; -.
DR PharmGKB; PA35860; -.
DR VEuPathDB; HostDB:ENSG00000102078; -.
DR eggNOG; KOG0753; Eukaryota.
DR GeneTree; ENSGT00940000159471; -.
DR InParanoid; O95258; -.
DR OMA; VWSNIIC; -.
DR PhylomeDB; O95258; -.
DR TreeFam; TF323211; -.
DR PathwayCommons; O95258; -.
DR Reactome; R-HSA-167826; The fatty acid cycling model.
DR Reactome; R-HSA-167827; The proton buffering model.
DR SignaLink; O95258; -.
DR BioGRID-ORCS; 9016; 7 hits in 700 CRISPR screens.
DR ChiTaRS; SLC25A14; human.
DR GeneWiki; SLC25A14; -.
DR GenomeRNAi; 9016; -.
DR Pharos; O95258; Tbio.
DR PRO; PR:O95258; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; O95258; protein.
DR Bgee; ENSG00000102078; Expressed in secondary oocyte and 191 other tissues.
DR ExpressionAtlas; O95258; baseline and differential.
DR Genevisible; O95258; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0005739; C:mitochondrion; TAS:ProtInc.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0015140; F:malate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015131; F:oxaloacetate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015141; F:succinate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015117; F:thiosulfate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0009060; P:aerobic respiration; TAS:ProtInc.
DR GO; GO:0071423; P:malate transmembrane transport; IBA:GO_Central.
DR GO; GO:0006839; P:mitochondrial transport; IEA:InterPro.
DR GO; GO:0015729; P:oxaloacetate transport; IBA:GO_Central.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0071422; P:succinate transmembrane transport; IBA:GO_Central.
DR GO; GO:0008272; P:sulfate transport; IBA:GO_Central.
DR GO; GO:0015709; P:thiosulfate transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002030; Mit_uncoupling_UCP-like.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR032933; SLC25A14.
DR PANTHER; PTHR45618:SF20; PTHR45618:SF20; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00784; MTUNCOUPLING.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..325
FT /note="Brain mitochondrial carrier protein 1"
FT /id="PRO_0000090677"
FT TRANSMEM 38..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..128
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..215
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..256
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..315
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 42..131
FT /note="Solcar 1"
FT REPEAT 139..224
FT /note="Solcar 2"
FT REPEAT 233..323
FT /note="Solcar 3"
FT VAR_SEQ 23..25
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_003272"
FT VAR_SEQ 198
FT /note="R -> RCLCSKAVTGCVLWLMPVIPALWEANAGGSLE (in isoform
FT 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_003273"
FT VARIANT 55
FT /note="E -> A (in dbSNP:rs2143598)"
FT /id="VAR_050138"
SQ SEQUENCE 325 AA; 36202 MW; 0447E8E3B5374982 CRC64;
MGIFPGIILI FLRVKFATAA VIVSGHQKST TVSHEMSGLN WKPFVYGGLA SIVAEFGTFP
VDLTKTRLQV QGQSIDARFK EIKYRGMFHA LFRICKEEGV LALYSGIAPA LLRQASYGTI
KIGIYQSLKR LFVERLEDET LLINMICGVV SGVISSTIAN PTDVLKIRMQ AQGSLFQGSM
IGSFIDIYQQ EGTRGLWRGV VPTAQRAAIV VGVELPVYDI TKKHLILSGM MGDTILTHFV
SSFTCGLAGA LASNPVDVVR TRMMNQRAIV GHVDLYKGTV DGILKMWKHE GFFALYKGFW
PNWLRLGPWN IIFFITYEQL KRLQI
