UCP5_MOUSE
ID UCP5_MOUSE Reviewed; 325 AA.
AC Q9Z2B2; Q9ESI8;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 19-DEC-2001, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Brain mitochondrial carrier protein 1;
DE Short=BMCP-1;
DE AltName: Full=Mitochondrial uncoupling protein 5;
DE Short=UCP 5;
DE AltName: Full=Solute carrier family 25 member 14;
GN Name=Slc25a14; Synonyms=Bmcp1, Ucp5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=BALB/cJ; TISSUE=Brain;
RX PubMed=9852133; DOI=10.1074/jbc.273.51.34611;
RA Sanchis D., Fleury C., Chomiki N., Goubern M., Huang Q., Neverova M.,
RA Gregoire F., Easlick J., Raimbault S., Levi-Meyrueis C., Miroux B.,
RA Collins S., Seldin M., Richard D., Warden C., Bouillaud F., Ricquier D.;
RT "BMCP1, a novel mitochondrial carrier with high expression in the central
RT nervous system of humans and rodents, and respiration uncoupling activity
RT in recombinant yeast.";
RL J. Biol. Chem. 273:34611-34615(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, AND TISSUE SPECIFICITY.
RX PubMed=10928996; DOI=10.1096/fj.99-0834com;
RA Yu X.X., Mao W., Zhong A., Schow P., Brush J., Sherwood S.W., Adams S.H.,
RA Pan G.;
RT "Characterization of novel UCP5/BMCP1 isoforms and differential regulation
RT of UCP4 and UCP5 expression through dietary or temperature manipulation.";
RL FASEB J. 14:1611-1618(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Participates in the mitochondrial proton leak measured in
CC brain mitochondria.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=UCP5L;
CC IsoId=Q9Z2B2-1; Sequence=Displayed;
CC Name=2; Synonyms=UCP5S;
CC IsoId=Q9Z2B2-2; Sequence=VSP_003274;
CC -!- TISSUE SPECIFICITY: Mainly expressed in brain, particularly abundant in
CC cortex, hippocampus thalamus, amygdala and hypothalamus. Expressed in
CC other tissues to a lesser extent. {ECO:0000269|PubMed:10928996}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AF076981; AAD03674.1; -; mRNA.
DR EMBL; AF155812; AAG29585.1; -; mRNA.
DR EMBL; AF155813; AAG29586.1; -; mRNA.
DR EMBL; BC048692; AAH48692.1; -; mRNA.
DR CCDS; CCDS30112.1; -. [Q9Z2B2-2]
DR CCDS; CCDS53066.1; -. [Q9Z2B2-1]
DR RefSeq; NP_001159922.1; NM_001166450.2. [Q9Z2B2-1]
DR RefSeq; NP_001277634.1; NM_001290705.1.
DR RefSeq; NP_035528.1; NM_011398.3. [Q9Z2B2-2]
DR RefSeq; XP_017173930.1; XM_017318441.1.
DR AlphaFoldDB; Q9Z2B2; -.
DR SMR; Q9Z2B2; -.
DR STRING; 10090.ENSMUSP00000033431; -.
DR PhosphoSitePlus; Q9Z2B2; -.
DR MaxQB; Q9Z2B2; -.
DR PaxDb; Q9Z2B2; -.
DR PRIDE; Q9Z2B2; -.
DR ProteomicsDB; 297864; -. [Q9Z2B2-1]
DR ProteomicsDB; 297865; -. [Q9Z2B2-2]
DR Antibodypedia; 16263; 95 antibodies from 26 providers.
DR DNASU; 20523; -.
DR Ensembl; ENSMUST00000033431; ENSMUSP00000033431; ENSMUSG00000031105. [Q9Z2B2-2]
DR Ensembl; ENSMUST00000114936; ENSMUSP00000110586; ENSMUSG00000031105. [Q9Z2B2-1]
DR Ensembl; ENSMUST00000177710; ENSMUSP00000136140; ENSMUSG00000031105. [Q9Z2B2-1]
DR GeneID; 20523; -.
DR KEGG; mmu:20523; -.
DR UCSC; uc009tco.3; mouse. [Q9Z2B2-2]
DR UCSC; uc009tcp.3; mouse. [Q9Z2B2-1]
DR CTD; 9016; -.
DR MGI; MGI:1330823; Slc25a14.
DR VEuPathDB; HostDB:ENSMUSG00000031105; -.
DR eggNOG; KOG0753; Eukaryota.
DR GeneTree; ENSGT00940000159471; -.
DR InParanoid; Q9Z2B2; -.
DR OrthoDB; 892773at2759; -.
DR PhylomeDB; Q9Z2B2; -.
DR TreeFam; TF323211; -.
DR Reactome; R-MMU-167826; The fatty acid cycling model.
DR Reactome; R-MMU-167827; The proton buffering model.
DR BioGRID-ORCS; 20523; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q9Z2B2; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9Z2B2; protein.
DR Bgee; ENSMUSG00000031105; Expressed in substantia nigra and 217 other tissues.
DR ExpressionAtlas; Q9Z2B2; baseline and differential.
DR Genevisible; Q9Z2B2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005740; C:mitochondrial envelope; IDA:MGI.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0015140; F:malate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015131; F:oxaloacetate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015141; F:succinate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015117; F:thiosulfate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071423; P:malate transmembrane transport; IBA:GO_Central.
DR GO; GO:0006839; P:mitochondrial transport; IEA:InterPro.
DR GO; GO:0015729; P:oxaloacetate transport; IBA:GO_Central.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0071422; P:succinate transmembrane transport; IBA:GO_Central.
DR GO; GO:0008272; P:sulfate transport; IBA:GO_Central.
DR GO; GO:0015709; P:thiosulfate transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002030; Mit_uncoupling_UCP-like.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR032933; SLC25A14.
DR PANTHER; PTHR45618:SF20; PTHR45618:SF20; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00784; MTUNCOUPLING.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..325
FT /note="Brain mitochondrial carrier protein 1"
FT /id="PRO_0000090678"
FT TRANSMEM 38..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..128
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..215
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..256
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..315
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 42..131
FT /note="Solcar 1"
FT REPEAT 139..224
FT /note="Solcar 2"
FT REPEAT 233..323
FT /note="Solcar 3"
FT VAR_SEQ 23..25
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9852133"
FT /id="VSP_003274"
SQ SEQUENCE 325 AA; 36286 MW; 19BF01EF12809D83 CRC64;
MGIFPGIILI FLRVKFATAA VIVSGHQKSS TLSHEMSGLN WKPFVYGGLA SIVAEFGTFP
VDLTKTRLQV QGQSIDVRFK EIKYRGMFHA LFRIYKEEGI LALYSGIAPA LLRQASYGTI
KIGIYQSLKR LFVERLEDET LLINMICGVV SGVISSTIAN PTDVLKIRMQ AQGSLFQGSM
IGSFIDIYQQ EGTRGLWRGV VPTAQRAAIV VGVELPVYDI TKKHLIVSGM LGDTILTHFV
SSFTCGLAGA LASNPVDVVR TRMMNQRAIV GHVDLYKGTL DGILKMWKHE GFFALYKGFW
PNWLRLGPWN IIFFITYEQL KRLQI
