UCP7_SCHPO
ID UCP7_SCHPO Reviewed; 697 AA.
AC O13773;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 143.
DE RecName: Full=UBA domain-containing protein 7;
GN Name=ucp7; ORFNames=SPAC17A5.12;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP IDENTIFICATION.
RX PubMed=11584278; DOI=10.1038/ncb1001-939;
RA Wilkinson C.R.M., Seeger M., Hartmann-Petersen R., Stone M., Wallace M.,
RA Semple C., Gordon C.;
RT "Proteins containing the UBA domain are able to bind to multi-ubiquitin
RT chains.";
RL Nat. Cell Biol. 3:939-943(2001).
CC -!- CAUTION: The initiator methionine may be further downstream.
CC {ECO:0000305}.
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DR EMBL; CU329670; CAB11512.1; -; Genomic_DNA.
DR PIR; T37827; T37827.
DR RefSeq; NP_593480.1; NM_001018913.1.
DR AlphaFoldDB; O13773; -.
DR SMR; O13773; -.
DR BioGRID; 278666; 2.
DR STRING; 4896.SPAC17A5.12.1; -.
DR iPTMnet; O13773; -.
DR MaxQB; O13773; -.
DR PaxDb; O13773; -.
DR PRIDE; O13773; -.
DR EnsemblFungi; SPAC17A5.12.1; SPAC17A5.12.1:pep; SPAC17A5.12.
DR GeneID; 2542191; -.
DR KEGG; spo:SPAC17A5.12; -.
DR PomBase; SPAC17A5.12; ucp7.
DR VEuPathDB; FungiDB:SPAC17A5.12; -.
DR eggNOG; KOG0431; Eukaryota.
DR eggNOG; KOG1124; Eukaryota.
DR HOGENOM; CLU_395452_0_0_1; -.
DR InParanoid; O13773; -.
DR OMA; TILWPEC; -.
DR PhylomeDB; O13773; -.
DR Reactome; R-SPO-8856828; Clathrin-mediated endocytosis.
DR PRO; PR:O13773; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0032991; C:protein-containing complex; NAS:PomBase.
DR GO; GO:0031982; C:vesicle; IBA:GO_Central.
DR GO; GO:0030276; F:clathrin binding; ISO:PomBase.
DR GO; GO:0030544; F:Hsp70 protein binding; ISM:PomBase.
DR GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; TAS:PomBase.
DR GO; GO:0043130; F:ubiquitin binding; ISM:PomBase.
DR GO; GO:0072318; P:clathrin coat disassembly; ISO:PomBase.
DR GO; GO:0072583; P:clathrin-dependent endocytosis; IBA:GO_Central.
DR Gene3D; 1.10.287.110; -; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR015940; UBA.
DR Pfam; PF00627; UBA; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW Chaperone; Reference proteome; TPR repeat.
FT CHAIN 1..697
FT /note="UBA domain-containing protein 7"
FT /id="PRO_0000071158"
FT DOMAIN 181..221
FT /note="UBA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00212"
FT REPEAT 412..445
FT /note="TPR"
FT DOMAIN 633..696
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT REGION 1..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 697 AA; 79484 MW; 43789C80AFC18767 CRC64;
MDDLLDFNFY DKSTPSNQNN YSNNNSRTPS YSLPAPVAQK KNAQIPLKAS KPEDPFANLF
QKKTDNKISL KELERQKVGT PDSNSTPKSS NYDPFENLEI LHQLSNTPRD KDAVIHDKIE
ENKRPISQPQ VSASEKVTLK DLSLEPHQPV SLPAFENIGS ETSIPFENHN EITNMNTAKD
KLSSNEMYEK LRDLGFSDDQ SRLALENSGS LEDAIEYILE KDNAKGQYRE GEAYEAFSDS
SAKTQFSDFQ ALSNQLKSQL FEKANDLWNI GRKKLRDAVE ERRAVKDPSK PRWMDASHDF
GREATPEILP KTPIPKRKPH KVPMNEKVSE DRITTNQSRS GNDESSLVDF LTSKSDNSSF
NFPSDTYEGT ENILETAYES TTARQVNNNK PGKSTVKKRE EETLNNMVSA LVEEQQSTGN
ELFRKGDFSQ AIEEFTNSLS QLPAKHTKRV PLLSNRSLCY QKVGDLKTCL QDVDELVDII
GEEKGHGESI RDKSMNDYYV KNMVRKAQVL EQLEKYQESL NIWKDLIADG QISKLYIDGK
HRCEAAISSH SSESHSKRTT QQPKSTPNHT NIKVKSERLQ HVRMAQQKAE QLDEERSRLR
EPVQQIVNKW KEGKESNLRA LLASLDTILW PECRWQKVSL SELVLPKKVK IAYMKAVSRV
HPDKLPQQTS VEHQLIAESA FSILNHAWEL FKQQNDL
