UCPA_DICDI
ID UCPA_DICDI Reviewed; 306 AA.
AC Q55BF4;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Mitochondrial substrate carrier family protein ucpA;
DE AltName: Full=Solute carrier family 25 member 35 homolog;
DE AltName: Full=Uncoupler protein A;
GN Name=ucpA; Synonyms=slc25a35; ORFNames=DDB_G0271310;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP REVIEW.
RX PubMed=17442478; DOI=10.1016/j.biochi.2007.03.004;
RA Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G.,
RA Klein G.;
RT "Mitochondrial carrier family: repertoire and peculiarities of the cellular
RT slime mould Dictyostelium discoideum.";
RL Biochimie 89:1058-1069(2007).
CC -!- FUNCTION: Mitochondrial solute carriers shuttle metabolites,
CC nucleotides, and cofactors through the mitochondrial inner membrane.
CC Transports oxaloacetate and sulfate (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Present with 5350 molecules/cell in log phase SD medium.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000006; EAL71785.1; -; Genomic_DNA.
DR RefSeq; XP_645658.1; XM_640566.1.
DR AlphaFoldDB; Q55BF4; -.
DR STRING; 44689.DDB0237606; -.
DR PaxDb; Q55BF4; -.
DR EnsemblProtists; EAL71785; EAL71785; DDB_G0271310.
DR GeneID; 8617850; -.
DR KEGG; ddi:DDB_G0271310; -.
DR dictyBase; DDB_G0271310; ucpA.
DR eggNOG; KOG0755; Eukaryota.
DR HOGENOM; CLU_015166_14_3_1; -.
DR InParanoid; Q55BF4; -.
DR OMA; VMSRMYN; -.
DR PhylomeDB; Q55BF4; -.
DR PRO; PR:Q55BF4; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; ISS:dictyBase.
DR GO; GO:0022857; F:transmembrane transporter activity; ISS:dictyBase.
DR GO; GO:0015729; P:oxaloacetate transport; ISS:dictyBase.
DR GO; GO:0008272; P:sulfate transport; ISS:dictyBase.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..306
FT /note="Mitochondrial substrate carrier family protein ucpA"
FT /id="PRO_0000385536"
FT TOPO_DOM 1..15
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 16..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..83
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 84..103
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..117
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 118..138
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..174
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 175..195
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..211
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 212..232
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..276
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 277..295
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..306
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT REPEAT 13..103
FT /note="Solcar 1"
FT REPEAT 112..204
FT /note="Solcar 2"
FT REPEAT 211..301
FT /note="Solcar 3"
SQ SEQUENCE 306 AA; 33605 MW; DA149C5E06C13BD4 CRC64;
MSVNLNNNKN NKNKVAIGFI SGSLASICAT TVTNPIELVK TRLQLQGELQ LSQRIYNGVW
DAFKQIYKTE GIRGLQSGLI PAYFSQATMQ GIRLGSFDLI SNALGAKPNQ DYFFLKNLLA
GATAGAIGAA AGSPFDLVKV RMQAANMYKN DPQFVGYSSS FAAFKQIIQK EGFKGLTRGM
LTSAQRTAVG SAIQLSTYGS CKNLVLNFVD DGIYAYIISS MVAGFIVTFG MNPFDVARTR
LYFQGKGNSH GEIYKGLMDC VYKTVKKEGF GAVYKGFWAH YLRLGPHTIL TLVFWEQFKK
LFSGEL
