ID   UCPA_ECO57              Reviewed;         263 AA.
AC   Q8XBJ4;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2002, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Oxidoreductase UcpA;
DE            EC=1.-.-.-;
GN   Name=ucpA; OrderedLocusNames=Z3691, ECs3297;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG57544.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB36720.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE005174; AAG57544.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000007; BAB36720.1; ALT_INIT; Genomic_DNA.
DR   PIR; A91041; A91041.
DR   PIR; D85885; D85885.
DR   RefSeq; NP_311324.2; NC_002695.1.
DR   RefSeq; WP_000517430.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8XBJ4; -.
DR   SMR; Q8XBJ4; -.
DR   STRING; 155864.EDL933_3589; -.
DR   EnsemblBacteria; AAG57544; AAG57544; Z3691.
DR   EnsemblBacteria; BAB36720; BAB36720; ECs_3297.
DR   GeneID; 915487; -.
DR   KEGG; ece:Z3691; -.
DR   KEGG; ecs:ECs_3297; -.
DR   PATRIC; fig|386585.9.peg.3444; -.
DR   eggNOG; COG1028; Bacteria.
DR   HOGENOM; CLU_010194_1_0_6; -.
DR   OMA; GALPHMY; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..263
FT                   /note="Oxidoreductase UcpA"
FT                   /id="PRO_0000054802"
FT   ACT_SITE        155
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         10..32
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         141
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   263 AA;  27832 MW;  32501713357E8E04 CRC64;
     MGKLTGKTAL ITGALQGIGE GIARTFARHG ANLILLDISP EIEKLADELC GRGHRCTAVV
     ADVRDPASVA AAIKRAKEKE GRIDILVNNA GVCRLGSFLD MSDDDRDFHI DINIKGVWNV
     TKAVLPEMIA RKDGRIVMMS SVTGDMVADP GETAYALTKA AIVGLTKSLA VEYAQSGIRV
     NAICPGYVRT PMAESIARQS NPEDPESVLT EMAKAIPLRR LADPLEVGEL AAFLASDESS
     YLTGTQNVID GGSTLPETVS VGI