UCPA_SALTY
ID UCPA_SALTY Reviewed; 263 AA.
AC P0A2D1; P37441;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Oxidoreductase UcpA;
DE EC=1.-.-.-;
GN Name=ucpA; OrderedLocusNames=STM2445;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 204-263.
RX PubMed=1909324; DOI=10.1128/jb.173.18.5876-5886.1991;
RA Hryniewicz M.M., Kredich N.M.;
RT "The cysP promoter of Salmonella typhimurium: characterization of two
RT binding sites for CysB protein, studies of in vivo transcription
RT initiation, and demonstration of the anti-inducer effects of thiosulfate.";
RL J. Bacteriol. 173:5876-5886(1991).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
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DR EMBL; AE006468; AAL21339.1; -; Genomic_DNA.
DR PIR; A38121; A38121.
DR RefSeq; NP_461380.1; NC_003197.2.
DR RefSeq; WP_000517460.1; NC_003197.2.
DR AlphaFoldDB; P0A2D1; -.
DR SMR; P0A2D1; -.
DR STRING; 99287.STM2445; -.
DR PaxDb; P0A2D1; -.
DR PRIDE; P0A2D1; -.
DR EnsemblBacteria; AAL21339; AAL21339; STM2445.
DR GeneID; 1253967; -.
DR KEGG; stm:STM2445; -.
DR PATRIC; fig|99287.12.peg.2583; -.
DR HOGENOM; CLU_010194_1_0_6; -.
DR OMA; NISSMWG; -.
DR PhylomeDB; P0A2D1; -.
DR BioCyc; SENT99287:STM2445-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 3: Inferred from homology;
KW Oxidoreductase; Reference proteome.
FT CHAIN 1..263
FT /note="Oxidoreductase UcpA"
FT /id="PRO_0000054804"
FT ACT_SITE 155
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 10..32
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT BINDING 141
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT CONFLICT 218
FT /note="L -> M (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 258
FT /note="S -> T (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 263
FT /note="V -> I (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 263 AA; 27870 MW; 81B26CAD9B4D534E CRC64;
MGKLTGKTAL ITGASQGIGE GIARVFARHG ANLILLDISD EIEKLADELG GRGHRCTAVK
ADVRDFASVQ AAVARAKETE GRIDILVNNA GVCRLGNFLD MSEEDRDFHI DINIKGVWNV
TKAVLPEMIK RKDGRIVMMS SVTGDMVADP GETAYALSKA AIVGLTKSLA VEYAQSGIRV
NAICPGYVRT PMAESIARQS NPDDPESVLT EMAKAIPLRR LADPLEVGEL AAFLASDESS
YLTGTQNVID GGSTLPESVS VGV