ID   UD2C1_RABIT             Reviewed;         502 AA.
AC   P36514;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=UDP-glucuronosyltransferase 2C1;
DE            Short=UDPGT 2C1;
DE            EC=2.4.1.17;
DE   Flags: Fragment;
GN   Name=UGT2C1; Synonyms=UGT2A2;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white; TISSUE=Liver;
RX   PubMed=8325897; DOI=10.1016/s0021-9258(18)82464-4;
RA   Tukey R.H., Pendurthi U.R., Nguyen N.T., Green M.D., Tephly T.R.;
RT   "Cloning and characterization of rabbit liver UDP-glucuronosyltransferase
RT   cDNAs. Developmental and inducible expression of 4-hydroxybiphenyl
RT   UGT2B13.";
RL   J. Biol. Chem. 268:15260-15266(1993).
CC   -!- FUNCTION: UDPGT is of major importance in the conjugation and
CC       subsequent elimination of potentially toxic xenobiotics and endogenous
CC       compounds.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC         beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC   -!- SUBCELLULAR LOCATION: Microsome membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}. Endoplasmic reticulum membrane
CC       {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; L01083; AAA18023.1; -; mRNA.
DR   AlphaFoldDB; P36514; -.
DR   SMR; P36514; -.
DR   STRING; 9986.ENSOCUP00000023419; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   eggNOG; KOG1192; Eukaryota.
DR   InParanoid; P36514; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Glycosyltransferase; Lipid metabolism;
KW   Membrane; Microsome; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           <1..502
FT                   /note="UDP-glucuronosyltransferase 2C1"
FT                   /id="PRO_0000074136"
FT   TRANSMEM        466..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        177
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        288
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   502 AA;  57449 MW;  B6E65670BFAE1D35 CRC64;
     AAAMDFSHWI NLKVILEELQ LRGHEITVLV PSPSLLLDHT KIPFNVEVLQ LQVTKETLME
     ELNTVLYMSS FELPTLSWWK VLGKMVEMGK QFSKNLRRVC DSAITNKELL DRLKAAKFDI
     CLADPLAFCG ELVAELLNIP FVYSFRFSIG NIIERSCAGL PTPSSYVPGS TSGLTDNMSF
     VQRLKNWLLY LMNDMMFSHF MLSEWDEYYS KVLGRRTTIC EIMGKAEMWL IRSYWDFEFP
     RPFLPNFEYV GGLHCKPAKP LPEELEEFVQ SSGNDGVVVF TLGSMIQNLT EERSNLIASA
     LAQIPQKVLW RYTGKKPATL GPNTRLFEWI PQNDLLGHPK TRAFITHGGT NGLYEAIYHG
     VPMVGIPLFG DQPDNIARVK AKGAAVDVDL RIMTTSSLLK ALKDVINNPS YKENAMKLSR
     IHHDQPLKPL DRAVFWIEFV MRHKGARHLR VAAHDLTWFQ YYSLDVVVFL LTCVATIIFL
     AKKCCLFFYR RFCKTGNKRK RE