ID   UD3A1_BOVIN             Reviewed;         523 AA.
AC   Q1LZI1;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=UDP-glucuronosyltransferase 3A1;
DE            Short=UDPGT 3A1;
DE            EC=2.4.1.17;
DE   Flags: Precursor;
GN   Name=UGT3A1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: UDP-glucuronosyltransferases catalyze phase II
CC       biotransformation reactions in which lipophilic substrates are
CC       conjugated with glucuronic acid to increase water solubility and
CC       enhance excretion. They are of major importance in the conjugation and
CC       subsequent elimination of potentially toxic xenobiotics and endogenous
CC       compounds (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC         beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; BC115988; AAI15989.1; -; mRNA.
DR   RefSeq; NP_001069555.1; NM_001076087.1.
DR   AlphaFoldDB; Q1LZI1; -.
DR   SMR; Q1LZI1; -.
DR   STRING; 9913.ENSBTAP00000003497; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   PaxDb; Q1LZI1; -.
DR   PRIDE; Q1LZI1; -.
DR   Ensembl; ENSBTAT00000003497; ENSBTAP00000003497; ENSBTAG00000002701.
DR   GeneID; 537188; -.
DR   KEGG; bta:537188; -.
DR   CTD; 167127; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002701; -.
DR   eggNOG; KOG1192; Eukaryota.
DR   GeneTree; ENSGT00940000161263; -.
DR   HOGENOM; CLU_012949_3_2_1; -.
DR   InParanoid; Q1LZI1; -.
DR   OMA; YASFQRP; -.
DR   OrthoDB; 508327at2759; -.
DR   TreeFam; TF315472; -.
DR   Proteomes; UP000009136; Chromosome 20.
DR   Bgee; ENSBTAG00000002701; Expressed in liver and 11 other tissues.
DR   ExpressionAtlas; Q1LZI1; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043541; C:UDP-N-acetylglucosamine transferase complex; IBA:GO_Central.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IBA:GO_Central.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Glycosyltransferase; Membrane; Reference proteome; Signal;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..523
FT                   /note="UDP-glucuronosyltransferase 3A1"
FT                   /id="PRO_0000299149"
FT   TOPO_DOM        23..483
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        484..504
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        505..523
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        52
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   523 AA;  59682 MW;  BBD64418540DD647 CRC64;
     MAGQQALLLF GFILPGLLFS EAAKILTVSL VGGSHFLLMH QISQILQDHG HNVTMLLQKG
     NLLLPGFKEE EKSYKVFNWF LPEDCNEEFK RSFHSFMEKT FGGRCKFEHF LNIMELLGHH
     CSHLLRRKDV MKSLKNENFD LVIVEMFDYC PFLVAEKLGK PFVAILPSAL GTVDFGLPSP
     LSYVPVFYSL LTDQMDFWGR VKNFLMFFEF FKKQWKIQSA YDDTIKEHFP DDSRPVLSHL
     LTKAELWFVN TDFAFDFARP LLPNTVCIGG LMSKPVKPVP QEFENFITKF GDSGFVLVSL
     GSMVSFIRSQ EVLKEMNAAF AHLPQGVIWK YNPSHWPKDI KLAPNVKIVH WLPQNDLLGH
     PRIRLFVSHG GMNSIMEAIQ HGVPMVGIPL FGDQHENLLR VKAKKFGVSI QLKQIKAETL
     ALKMKQVIED KRYKSAAEAA SIIRRSQPLT PAQRLVGWIN HILQTGGAAH LKPHAFQQPW
     YEQYLLDVFL FLLVVTLGTM WLCGKLLGLV ARWLCGARKL KKA