UD3A1_HUMAN
ID UD3A1_HUMAN Reviewed; 523 AA.
AC Q6NUS8; G5E961; Q8IYS9; Q8NAW4; Q96DM6;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=UDP-glucuronosyltransferase 3A1;
DE Short=UDPGT 3A1;
DE EC=2.4.1.17;
DE Flags: Precursor;
GN Name=UGT3A1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Kidney, and Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: UDP-glucuronosyltransferases catalyze phase II
CC biotransformation reactions in which lipophilic substrates are
CC conjugated with glucuronic acid to increase water solubility and
CC enhance excretion. They are of major importance in the conjugation and
CC subsequent elimination of potentially toxic xenobiotics and endogenous
CC compounds (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6NUS8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6NUS8-2; Sequence=VSP_044985, VSP_044986, VSP_044987;
CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC {ECO:0000305}.
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DR EMBL; AK057066; BAB71358.1; -; mRNA.
DR EMBL; AK091977; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC016612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC112204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471119; EAW55928.1; -; Genomic_DNA.
DR EMBL; BC035012; AAH35012.1; -; mRNA.
DR EMBL; BC068446; AAH68446.1; -; mRNA.
DR CCDS; CCDS3913.1; -. [Q6NUS8-1]
DR CCDS; CCDS54841.1; -. [Q6NUS8-2]
DR RefSeq; NP_001165344.1; NM_001171873.1. [Q6NUS8-2]
DR RefSeq; NP_689617.3; NM_152404.3. [Q6NUS8-1]
DR AlphaFoldDB; Q6NUS8; -.
DR SMR; Q6NUS8; -.
DR BioGRID; 126370; 12.
DR STRING; 9606.ENSP00000274278; -.
DR DrugBank; DB01852; Kaempherol.
DR DrugBank; DB04216; Quercetin.
DR CAZy; GT1; Glycosyltransferase Family 1.
DR GlyGen; Q6NUS8; 1 site.
DR iPTMnet; Q6NUS8; -.
DR PhosphoSitePlus; Q6NUS8; -.
DR BioMuta; UGT3A1; -.
DR DMDM; 74749002; -.
DR EPD; Q6NUS8; -.
DR jPOST; Q6NUS8; -.
DR MassIVE; Q6NUS8; -.
DR PaxDb; Q6NUS8; -.
DR PeptideAtlas; Q6NUS8; -.
DR PRIDE; Q6NUS8; -.
DR ProteomicsDB; 33841; -.
DR ProteomicsDB; 66710; -. [Q6NUS8-1]
DR Antibodypedia; 22897; 41 antibodies from 15 providers.
DR DNASU; 133688; -.
DR Ensembl; ENST00000274278.8; ENSP00000274278.3; ENSG00000145626.12. [Q6NUS8-1]
DR Ensembl; ENST00000333811.5; ENSP00000328033.4; ENSG00000145626.12. [Q6NUS8-2]
DR Ensembl; ENST00000625798.2; ENSP00000487376.1; ENSG00000145626.12. [Q6NUS8-2]
DR GeneID; 133688; -.
DR KEGG; hsa:133688; -.
DR MANE-Select; ENST00000274278.8; ENSP00000274278.3; NM_152404.4; NP_689617.3.
DR UCSC; uc003jjv.3; human. [Q6NUS8-1]
DR CTD; 133688; -.
DR GeneCards; UGT3A1; -.
DR HGNC; HGNC:26625; UGT3A1.
DR HPA; ENSG00000145626; Group enriched (kidney, liver).
DR MIM; 616383; gene.
DR neXtProt; NX_Q6NUS8; -.
DR OpenTargets; ENSG00000145626; -.
DR PharmGKB; PA142670642; -.
DR VEuPathDB; HostDB:ENSG00000145626; -.
DR eggNOG; KOG1192; Eukaryota.
DR GeneTree; ENSGT00940000163740; -.
DR InParanoid; Q6NUS8; -.
DR OMA; VGPIMPV; -.
DR PhylomeDB; Q6NUS8; -.
DR TreeFam; TF315472; -.
DR BRENDA; 2.4.1.17; 2681.
DR PathwayCommons; Q6NUS8; -.
DR Reactome; R-HSA-156588; Glucuronidation.
DR Reactome; R-HSA-9749641; Aspirin ADME.
DR BioGRID-ORCS; 133688; 9 hits in 1071 CRISPR screens.
DR ChiTaRS; UGT3A1; human.
DR GenomeRNAi; 133688; -.
DR Pharos; Q6NUS8; Tdark.
DR PRO; PR:Q6NUS8; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q6NUS8; protein.
DR Bgee; ENSG00000145626; Expressed in kidney epithelium and 51 other tissues.
DR ExpressionAtlas; Q6NUS8; baseline and differential.
DR Genevisible; Q6NUS8; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043541; C:UDP-N-acetylglucosamine transferase complex; IDA:MGI.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IDA:MGI.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IDA:MGI.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR InterPro; IPR002213; UDP_glucos_trans.
DR InterPro; IPR035595; UDP_glycos_trans_CS.
DR Pfam; PF00201; UDPGT; 1.
DR PROSITE; PS00375; UDPGT; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Glycosyltransferase; Membrane;
KW Reference proteome; Signal; Transferase; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..523
FT /note="UDP-glucuronosyltransferase 3A1"
FT /id="PRO_0000299150"
FT TOPO_DOM 23..483
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 484..504
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 505..523
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 52
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..54
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_044985"
FT VAR_SEQ 282..306
FT /note="DLDNFIANFGDAGFVLVAFGSMLNT -> NGQPALFTTPSLFSSGVYPEPLR
FT WL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_044986"
FT VAR_SEQ 307..523
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_044987"
FT VARIANT 121
FT /note="C -> G (in dbSNP:rs3756669)"
FT /id="VAR_034791"
FT CONFLICT 139
FT /note="Y -> C (in Ref. 1; BAB71358)"
FT /evidence="ECO:0000305"
FT CONFLICT 378
FT /note="A -> T (in Ref. 1; BAB71358)"
FT /evidence="ECO:0000305"
FT CONFLICT 475
FT /note="A -> V (in Ref. 1; BAB71358)"
FT /evidence="ECO:0000305"
FT CONFLICT Q6NUS8-2:251
FT /note="W -> R (in Ref. 2; AAH35012)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 523 AA; 59151 MW; 602AE3D75CE986BD CRC64;
MVGQRVLLLV AFLLSGVLLS EAAKILTIST LGGSHYLLLD RVSQILQEHG HNVTMLHQSG
KFLIPDIKEE EKSYQVIRWF SPEDHQKRIK KHFDSYIETA LDGRKESEAL VKLMEIFGTQ
CSYLLSRKDI MDSLKNENYD LVFVEAFDFC SFLIAEKLVK PFVAILPTTF GSLDFGLPSP
LSYVPVFPSL LTDHMDFWGR VKNFLMFFSF SRSQWDMQST FDNTIKEHFP EGSRPVLSHL
LLKAELWFVN SDFAFDFARP LLPNTVYIGG LMEKPIKPVP QDLDNFIANF GDAGFVLVAF
GSMLNTHQSQ EVLKKMHNAF AHLPQGVIWT CQSSHWPRDV HLATNVKIVD WLPQSDLLAH
PSIRLFVTHG GQNSVMEAIR HGVPMVGLPV NGDQHGNMVR VVAKNYGVSI RLNQVTADTL
TLTMKQVIED KRYKSAVVAA SVILHSQPLS PAQRLVGWID HILQTGGATH LKPYAFQQPW
HEQYLIDVFV FLLGLTLGTM WLCGKLLGVV ARWLRGARKV KKT
