UDB11_HUMAN
ID UDB11_HUMAN Reviewed; 529 AA.
AC O75310; Q3KNV9;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=UDP-glucuronosyltransferase 2B11;
DE Short=UDPGT 2B11;
DE EC=2.4.1.17;
DE Flags: Precursor;
GN Name=UGT2B11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9675083; DOI=10.1006/bbrc.1998.8908;
RA Beaulieu M., Levesque E., Hum D.W., Belanger A.;
RT "Isolation and characterization of a human orphan UDP-
RT glucuronosyltransferase, UGT2B11.";
RL Biochem. Biophys. Res. Commun. 248:44-50(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: UDPGT is of major importance in the conjugation and
CC subsequent elimination of potentially toxic xenobiotics and endogenous
CC compounds.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC -!- INTERACTION:
CC O75310; Q12797-6: ASPH; NbExp=3; IntAct=EBI-12891746, EBI-12092171;
CC O75310; P55061: TMBIM6; NbExp=3; IntAct=EBI-12891746, EBI-1045825;
CC -!- SUBCELLULAR LOCATION: Microsome membrane {ECO:0000305}; Single-pass
CC membrane protein {ECO:0000305}. Endoplasmic reticulum membrane
CC {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Widely expressed.
CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC {ECO:0000305}.
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DR EMBL; AF016492; AAC27891.1; -; mRNA.
DR EMBL; BC069441; AAH69441.1; -; mRNA.
DR EMBL; BC107059; AAI07060.1; -; mRNA.
DR EMBL; BC107060; AAI07061.1; -; mRNA.
DR CCDS; CCDS3527.1; -.
DR PIR; JE0200; JE0200.
DR RefSeq; NP_001064.1; NM_001073.2.
DR AlphaFoldDB; O75310; -.
DR SMR; O75310; -.
DR BioGRID; 115945; 6.
DR IntAct; O75310; 2.
DR STRING; 9606.ENSP00000387683; -.
DR ChEMBL; CHEMBL4523985; -.
DR CAZy; GT1; Glycosyltransferase Family 1.
DR GlyGen; O75310; 1 site.
DR iPTMnet; O75310; -.
DR PhosphoSitePlus; O75310; -.
DR BioMuta; UGT2B11; -.
DR jPOST; O75310; -.
DR MassIVE; O75310; -.
DR PaxDb; O75310; -.
DR PeptideAtlas; O75310; -.
DR PRIDE; O75310; -.
DR ProteomicsDB; 49886; -.
DR Antibodypedia; 57751; 56 antibodies from 13 providers.
DR DNASU; 10720; -.
DR Ensembl; ENST00000446444.2; ENSP00000387683.1; ENSG00000213759.10.
DR GeneID; 10720; -.
DR KEGG; hsa:10720; -.
DR MANE-Select; ENST00000446444.2; ENSP00000387683.1; NM_001073.3; NP_001064.1.
DR UCSC; uc003heh.5; human.
DR CTD; 10720; -.
DR DisGeNET; 10720; -.
DR GeneCards; UGT2B11; -.
DR HGNC; HGNC:12545; UGT2B11.
DR HPA; ENSG00000213759; Tissue enriched (breast).
DR MIM; 603064; gene.
DR neXtProt; NX_O75310; -.
DR OpenTargets; ENSG00000213759; -.
DR PharmGKB; PA37187; -.
DR VEuPathDB; HostDB:ENSG00000213759; -.
DR eggNOG; KOG1192; Eukaryota.
DR GeneTree; ENSGT00940000165281; -.
DR HOGENOM; CLU_012949_0_2_1; -.
DR InParanoid; O75310; -.
DR OMA; WINNALY; -.
DR OrthoDB; 508327at2759; -.
DR PhylomeDB; O75310; -.
DR TreeFam; TF315472; -.
DR BRENDA; 2.4.1.17; 2681.
DR PathwayCommons; O75310; -.
DR Reactome; R-HSA-156588; Glucuronidation.
DR Reactome; R-HSA-9749641; Aspirin ADME.
DR SignaLink; O75310; -.
DR BioGRID-ORCS; 10720; 23 hits in 988 CRISPR screens.
DR ChiTaRS; UGT2B11; human.
DR GenomeRNAi; 10720; -.
DR Pharos; O75310; Tbio.
DR PRO; PR:O75310; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; O75310; protein.
DR Bgee; ENSG00000213759; Expressed in liver and 43 other tissues.
DR Genevisible; O75310; HS.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IDA:UniProtKB.
DR GO; GO:0052695; P:cellular glucuronidation; IBA:GO_Central.
DR GO; GO:0008210; P:estrogen metabolic process; IDA:UniProtKB.
DR GO; GO:0052697; P:xenobiotic glucuronidation; IDA:UniProtKB.
DR GO; GO:0006805; P:xenobiotic metabolic process; TAS:ProtInc.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR InterPro; IPR002213; UDP_glucos_trans.
DR InterPro; IPR035595; UDP_glycos_trans_CS.
DR Pfam; PF00201; UDPGT; 1.
DR PROSITE; PS00375; UDPGT; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Glycoprotein; Glycosyltransferase; Membrane;
KW Microsome; Reference proteome; Signal; Transferase; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..529
FT /note="UDP-glucuronosyltransferase 2B11"
FT /id="PRO_0000036035"
FT TRANSMEM 493..513
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 135
FT /note="N6-succinyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q8BWQ1"
FT CARBOHYD 315
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 529 AA; 61038 MW; CE4AC3C71CFC2AB4 CRC64;
MTLKWTSVLL LIHLSCYFSS GSCGKVLVWA AEYSHWMNMK TILKELVQRG HEVTVLASSA
SILFDPNDAS TLKFEVYPTS LTKTEFENII MQQVKRWSDI RKDSFWLYFS QEQEILWELY
DIFRNFCKDV VSNKKVMKKL QESRFDIVFA DAVFPCGELL AALLNIRFVY SLRFTPGYTI
ERHSGGLIFP PSYIPIVMSK LSDQMTFMER VKNMIYVLYF DFWFQMSDMK KWDQFYSEVL
GRPTTLFETM GKADIWLMRN SWSFQFPHPF LPNVDFVGGF HCKPAKPLPK EMEEFVQSSG
ENGVVVFSLG SVISNMTAER ANVIATALAK IPQKVLWRFD GNKPDALGLN TRLYKWIPQN
DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGIPLFFDQP DNIAHMKAKG AAVRLDFNTM
SSTDLLNALK TVINDPLYKE NIMKLSRIQH DQPVKPLDRA VFWIEFVMPH KGAKHLRVAA
HDLTWFQYHS LDVIGFLLAC VATVIFIITK FCLFCFWKFA RKGKKGKRD
