ID   UDB14_RABIT             Reviewed;         530 AA.
AC   P36513;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=UDP-glucuronosyltransferase 2B14;
DE            Short=UDPGT 2B14;
DE            EC=2.4.1.17;
DE   AltName: Full=EGT12;
DE   Flags: Precursor;
GN   Name=UGT2B14;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white; TISSUE=Liver;
RX   PubMed=8325897; DOI=10.1016/s0021-9258(18)82464-4;
RA   Tukey R.H., Pendurthi U.R., Nguyen N.T., Green M.D., Tephly T.R.;
RT   "Cloning and characterization of rabbit liver UDP-glucuronosyltransferase
RT   cDNAs. Developmental and inducible expression of 4-hydroxybiphenyl
RT   UGT2B13.";
RL   J. Biol. Chem. 268:15260-15266(1993).
CC   -!- FUNCTION: UDPGT is of major importance in the conjugation and
CC       subsequent elimination of potentially toxic xenobiotics and endogenous
CC       compounds.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC         beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC   -!- SUBCELLULAR LOCATION: Microsome membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}. Endoplasmic reticulum membrane
CC       {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expressed primarily in adult rabbits.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; L01082; AAA18021.1; -; mRNA.
DR   PIR; C47113; C47113.
DR   RefSeq; NP_001075709.1; NM_001082240.1.
DR   AlphaFoldDB; P36513; -.
DR   SMR; P36513; -.
DR   STRING; 9986.ENSOCUP00000014798; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   GeneID; 100009057; -.
DR   KEGG; ocu:100009057; -.
DR   CTD; 100009057; -.
DR   eggNOG; KOG1192; Eukaryota.
DR   InParanoid; P36513; -.
DR   OrthoDB; 508327at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Glycosyltransferase; Membrane;
KW   Microsome; Reference proteome; Signal; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250"
FT   CHAIN           25..530
FT                   /note="UDP-glucuronosyltransferase 2B14"
FT                   /id="PRO_0000036038"
FT   TRANSMEM        494..510
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        134
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        316
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   530 AA;  60665 MW;  CEAA4BF25B53CB35 CRC64;
     MSVKHVSVLL LLLQLSCCFR TGSCGKVLVW PMDFSLWMNL NVILDELVRR GHEVIVLRNS
     ASIFIDPSKQ ANIKFETFPI AATKDDLEDL FVHYVSTWTN ARQNSQWKYF SLLQKLFSEY
     SDSCENACKE VVFNKTLMTK LQESRFDILL SDAIGPCGEL LAELLKIPFV YSLRFTPGYT
     MEKYSGGLSV PPSYVPIILS DLSGKMTFME RVNNMLCMLY FDFWFQMFNK KRWDQFYSEV
     LGRPVTFSEL VGKADMWLIR SYWDLEFPRP TLPNIQFVGG LHCKPAKPLP KEMEEFVQSS
     GEEGVVVFSL GSMVSNMTEE RANLIASAFA QLPQKVIWRF DGQKPETLGP NTRIYDWIPQ
     NDLLGHPKTK AFVTHGGANG IYEAIHHGIP MVGLPLFGEQ PDNIAHMTAK GAAIRLNWKT
     MSSEDLLNAL KTVINDPSYK ENVMTLSSIH HDQPMKPLDR AVFWIEYVMR HKGAKHLRVA
     AHDLTWFQYH SLDVVGFLVS CAAFLIFLVI KSYLFVYQKL VKIGKKQKRD