ID   UDDP_SULAC              Reviewed;         206 AA.
AC   P80143; Q4J9Z3; Q70SU5;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 2.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Undecaprenyl-diphosphatase;
DE            EC=3.6.1.27;
DE   AltName: Full=Dolicholpyrophosphatase;
GN   Name=sepP; OrderedLocusNames=Saci_1025;
OS   Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC
OS   15157 / NCIMB 11770).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=330779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RA   Schafer G., Moll R.G.;
RT   "The exo-ppase gene of the hyperthermophilic and acidophilic crenarchaeon
RT   Sulfolobus acidocaldarius.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX   PubMed=15995215; DOI=10.1128/jb.187.14.4992-4999.2005;
RA   Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E.,
RA   Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.;
RT   "The genome of Sulfolobus acidocaldarius, a model organism of the
RT   Crenarchaeota.";
RL   J. Bacteriol. 187:4992-4999(2005).
RN   [3]
RP   PROTEIN SEQUENCE OF 1-30.
RC   STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX   PubMed=1321720; DOI=10.1111/j.1432-1033.1992.tb17104.x;
RA   Meyer W., Schaefer G.;
RT   "Characterization and purification of a membrane-bound archaebacterial
RT   pyrophosphatase from Sulfolobus acidocaldarius.";
RL   Eur. J. Biochem. 207:741-746(1992).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-
CC         trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate;
CC         Xref=Rhea:RHEA:28094, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58405, ChEBI:CHEBI:60392; EC=3.6.1.27;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- INDUCTION: By polar lipids.
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DR   EMBL; AJ550389; CAD79428.1; -; Genomic_DNA.
DR   EMBL; CP000077; AAY80382.1; -; Genomic_DNA.
DR   PIR; S24152; S24152.
DR   RefSeq; WP_011277884.1; NC_007181.1.
DR   AlphaFoldDB; P80143; -.
DR   SMR; P80143; -.
DR   STRING; 330779.Saci_1025; -.
DR   EnsemblBacteria; AAY80382; AAY80382; Saci_1025.
DR   GeneID; 14551534; -.
DR   GeneID; 3472983; -.
DR   KEGG; sai:Saci_1025; -.
DR   PATRIC; fig|330779.12.peg.982; -.
DR   eggNOG; arCOG03056; Archaea.
DR   HOGENOM; CLU_072573_10_1_2; -.
DR   OMA; EPRPYEM; -.
DR   Proteomes; UP000001018; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050380; F:undecaprenyl-diphosphatase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR   InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR   Pfam; PF01569; PAP2; 1.
DR   SMART; SM00014; acidPPc; 1.
DR   SUPFAM; SSF48317; SSF48317; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Direct protein sequencing; Hydrolase; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..206
FT                   /note="Undecaprenyl-diphosphatase"
FT                   /id="PRO_0000065717"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   206 AA;  23525 MW;  02E314C4DCDC9340 CRC64;
     MRKYYYWILL LLFLILSIYI KLIGGEQNIG FNVELFKLIN YNQIATLNGL MVFLSKYGRE
     YVWIPVTALL LIFKRTRKIG ITLVISFVIA IVLGEVSKYV MAQLRPFNFV NPTYLLEPKP
     TDYSYPSGHA LIVSTGAVTL LLTSPKWMWI LGIIEAVLVS YSRVYVGVHW PLDVIAGWLL
     GSWISFLSVQ IESTGPIKKI EQMLKA