ID   UDGB_MYCBO              Reviewed;         268 AA.
AC   P64786; A0A1R3XXT5; Q11059; X2BHG5;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Type-5 uracil-DNA glycosylase {ECO:0000250|UniProtKB:P9WM53};
DE            EC=3.2.2.- {ECO:0000250|UniProtKB:P9WM53};
GN   Name=udgB {ECO:0000250|UniProtKB:P9WM53}; OrderedLocusNames=BQ2027_MB1289;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: DNA glycosylase with broad substrate specificity.
CC       {ECO:0000250|UniProtKB:P9WM53}.
CC   -!- SIMILARITY: Belongs to the uracil-DNA glycosylase (UDG) superfamily.
CC       Type 5 (UDGb) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=SIT99890.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; LT708304; SIT99890.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_854943.1; NC_002945.3.
DR   AlphaFoldDB; P64786; -.
DR   SMR; P64786; -.
DR   EnsemblBacteria; SIT99890; SIT99890; BQ2027_MB1289.
DR   PATRIC; fig|233413.5.peg.1414; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0033958; F:DNA-deoxyinosine glycosylase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004844; F:uracil DNA N-glycosylase activity; IEA:InterPro.
DR   GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR   CDD; cd10031; UDG-F5_TTUDGB_like; 1.
DR   Gene3D; 3.40.470.10; -; 1.
DR   InterPro; IPR044147; UdgB-like.
DR   InterPro; IPR005122; Uracil-DNA_glycosylase-like.
DR   InterPro; IPR036895; Uracil-DNA_glycosylase-like_sf.
DR   Pfam; PF03167; UDG; 1.
DR   SMART; SM00986; UDG; 1.
DR   SUPFAM; SSF52141; SSF52141; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; DNA damage; DNA repair; Hydrolase; Iron; Iron-sulfur;
KW   Metal-binding.
FT   CHAIN           1..268
FT                   /note="Type-5 uracil-DNA glycosylase"
FT                   /id="PRO_0000103775"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         57
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000250|UniProtKB:Q5SJ65"
FT   BINDING         60
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000250|UniProtKB:Q5SJ65"
FT   BINDING         161
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000250|UniProtKB:Q5SJ65"
FT   BINDING         176
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000250|UniProtKB:Q5SJ65"
SQ   SEQUENCE   268 AA;  28500 MW;  6F2C31C9C561E7FD CRC64;
     MHPKTGRAFR SPVEPGSGWP GDPATPQTPV AADAAQVSAL AGGAGSICEL NALISVCRAC
     PRLVSWREEV AVVKRRAFAD QPYWGRPVPG WGSKRPRLLI LGLAPAAHGA NRTGRMFTGD
     RSGDQLYAAL HRAGLVNSPV SVDAADGLRA NRIRITAPVR CAPPGNSPTP AERLTCSPWL
     NAEWRLVSDH IRAIVALGGF AWQVALRLAG ASGTPKPRFG HGVVTELGAG VRLLGCYHPS
     QQNMFTGRLT PTMLDDIFRE AKKLAGIE