UDGB_MYCLE
ID UDGB_MYCLE Reviewed; 229 AA.
AC Q9CC91;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Type-5 uracil-DNA glycosylase {ECO:0000250|UniProtKB:P9WM53};
DE EC=3.2.2.- {ECO:0000250|UniProtKB:P9WM53};
GN Name=udgB {ECO:0000250|UniProtKB:P9WM53}; OrderedLocusNames=ML1105;
OS Mycobacterium leprae (strain TN).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=272631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN;
RX PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
CC -!- FUNCTION: DNA glycosylase with broad substrate specificity.
CC {ECO:0000250|UniProtKB:P9WM53}.
CC -!- SIMILARITY: Belongs to the uracil-DNA glycosylase (UDG) superfamily.
CC Type 5 (UDGb) family. {ECO:0000305}.
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DR EMBL; AL583920; CAC31486.1; -; Genomic_DNA.
DR PIR; C87047; C87047.
DR RefSeq; NP_301808.1; NC_002677.1.
DR RefSeq; WP_010908132.1; NC_002677.1.
DR AlphaFoldDB; Q9CC91; -.
DR SMR; Q9CC91; -.
DR EnsemblBacteria; CAC31486; CAC31486; CAC31486.
DR KEGG; mle:ML1105; -.
DR PATRIC; fig|272631.5.peg.1987; -.
DR Leproma; ML1105; -.
DR eggNOG; COG1573; Bacteria.
DR HOGENOM; CLU_083279_0_0_11; -.
DR OMA; CVPPQNK; -.
DR Proteomes; UP000000806; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0033958; F:DNA-deoxyinosine glycosylase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004844; F:uracil DNA N-glycosylase activity; IEA:InterPro.
DR GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR CDD; cd10031; UDG-F5_TTUDGB_like; 1.
DR Gene3D; 3.40.470.10; -; 1.
DR InterPro; IPR044147; UdgB-like.
DR InterPro; IPR005122; Uracil-DNA_glycosylase-like.
DR InterPro; IPR036895; Uracil-DNA_glycosylase-like_sf.
DR Pfam; PF03167; UDG; 1.
DR SMART; SM00986; UDG; 1.
DR SUPFAM; SSF52141; SSF52141; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; DNA damage; DNA repair; Hydrolase; Iron; Iron-sulfur;
KW Metal-binding; Reference proteome.
FT CHAIN 1..229
FT /note="Type-5 uracil-DNA glycosylase"
FT /id="PRO_0000103776"
FT BINDING 19
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000250|UniProtKB:Q5SJ65"
FT BINDING 22
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000250|UniProtKB:Q5SJ65"
FT BINDING 123
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000250|UniProtKB:Q5SJ65"
FT BINDING 138
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000250|UniProtKB:Q5SJ65"
SQ SEQUENCE 229 AA; 24937 MW; 4E5A08DA11A4BEA3 CRC64;
MLSGGAGSIP ELNAQISVCR ACPRLVDWRE EVAVVKRRAF ADQPYWGRPV PGWGSEQPRL
LIVGLAPAAH GANRTGRMFT GDRSGDQLYA ALHRAGLVNL PISMDAADGL QANQIRITAP
VRCAPPGNAP TQAEWVTCSP WLEAEWRLVS EYVRAIVALG GFAWQIVLRL PGVSAMRKPR
FSHGVVAQLY AGVRLLGCYH PSQQNMFTGR LTPAMLDDIF RDAKKLAGI
