UDGB_MYCTO
ID UDGB_MYCTO Reviewed; 268 AA.
AC P9WM52; L0T7R5; P64785; Q11059;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 32.
DE RecName: Full=Type-5 uracil-DNA glycosylase {ECO:0000250|UniProtKB:P9WM53};
DE EC=3.2.2.- {ECO:0000250|UniProtKB:P9WM53};
GN Name=udgB {ECO:0000250|UniProtKB:P9WM53}; OrderedLocusNames=MT1297.1;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- FUNCTION: DNA glycosylase with broad substrate specificity.
CC {ECO:0000250|UniProtKB:P9WM53}.
CC -!- SIMILARITY: Belongs to the uracil-DNA glycosylase (UDG) superfamily.
CC Type 5 (UDGb) family. {ECO:0000305}.
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DR EMBL; AE000516; AAK45556.1; -; Genomic_DNA.
DR PIR; C70753; C70753.
DR AlphaFoldDB; P9WM52; -.
DR SMR; P9WM52; -.
DR EnsemblBacteria; AAK45556; AAK45556; MT1297.1.
DR KEGG; mtc:MT1297.1; -.
DR HOGENOM; CLU_083279_0_0_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0033958; F:DNA-deoxyinosine glycosylase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004844; F:uracil DNA N-glycosylase activity; IEA:InterPro.
DR GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR CDD; cd10031; UDG-F5_TTUDGB_like; 1.
DR Gene3D; 3.40.470.10; -; 1.
DR InterPro; IPR044147; UdgB-like.
DR InterPro; IPR005122; Uracil-DNA_glycosylase-like.
DR InterPro; IPR036895; Uracil-DNA_glycosylase-like_sf.
DR Pfam; PF03167; UDG; 1.
DR SMART; SM00986; UDG; 1.
DR SUPFAM; SSF52141; SSF52141; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; DNA damage; DNA repair; Hydrolase; Iron; Iron-sulfur;
KW Metal-binding.
FT CHAIN 1..268
FT /note="Type-5 uracil-DNA glycosylase"
FT /id="PRO_0000427364"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 57
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000250|UniProtKB:Q5SJ65"
FT BINDING 60
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000250|UniProtKB:Q5SJ65"
FT BINDING 161
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000250|UniProtKB:Q5SJ65"
FT BINDING 176
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000250|UniProtKB:Q5SJ65"
SQ SEQUENCE 268 AA; 28500 MW; 6F2C31C9C561E7FD CRC64;
MHPKTGRAFR SPVEPGSGWP GDPATPQTPV AADAAQVSAL AGGAGSICEL NALISVCRAC
PRLVSWREEV AVVKRRAFAD QPYWGRPVPG WGSKRPRLLI LGLAPAAHGA NRTGRMFTGD
RSGDQLYAAL HRAGLVNSPV SVDAADGLRA NRIRITAPVR CAPPGNSPTP AERLTCSPWL
NAEWRLVSDH IRAIVALGGF AWQVALRLAG ASGTPKPRFG HGVVTELGAG VRLLGCYHPS
QQNMFTGRLT PTMLDDIFRE AKKLAGIE
