ID   UDPE_NPVCD              Reviewed;         493 AA.
AC   Q90158;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2004, sequence version 2.
DT   23-FEB-2022, entry version 70.
DE   RecName: Full=Ecdysteroid UDP-glucosyltransferase;
DE            EC=2.4.1.-;
DE   Flags: Precursor;
GN   Name=egt; Synonyms=UGT21A3; ORFNames=Op14/Ac15;
OS   Choristoneura fumiferana defective polyhedrosis virus (Cfdef).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=74660;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7595348; DOI=10.1099/0022-1317-76-10-2447;
RA   Barrett J.W., Krell P.J., Arif B.M.;
RT   "Characterization, sequencing and phylogeny of the ecdysteroid UDP-
RT   glucosyltransferase gene from two distinct nuclear polyhedrosis viruses
RT   isolated from Choristoneura fumiferana.";
RL   J. Gen. Virol. 76:2447-2456(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION TO 312.
RX   PubMed=15784888; DOI=10.1099/vir.0.80489-0;
RA   Lauzon H.A., Jamieson P.B., Krell P.J., Arif B.M.;
RT   "Gene organization and sequencing of the Choristoneura fumiferana defective
RT   nucleopolyhedrovirus genome.";
RL   J. Gen. Virol. 86:945-961(2005).
CC   -!- FUNCTION: Catalyzes the transfer of glucose from UDP-glucose to
CC       ecdysteroids which are insect molting hormones. Expression of egt
CC       interferes with normal insect development and block molting (By
CC       similarity). {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Peaks around 12 hours p.i.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; AY327402; AAC09376.2; -; Genomic_DNA.
DR   RefSeq; NP_932625.1; NC_005137.2.
DR   SMR; Q90158; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   PRIDE; Q90158; -.
DR   GeneID; 2943836; -.
DR   KEGG; vg:2943836; -.
DR   Proteomes; UP000202937; Genome.
DR   GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR016224; Ecdysteroid_UDP-Glc_Trfase.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PIRSF; PIRSF000476; Ecdystd_UDP_glucosyltfrase; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   2: Evidence at transcript level;
KW   Glycosyltransferase; Reference proteome; Signal; Transferase.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..493
FT                   /note="Ecdysteroid UDP-glucosyltransferase"
FT                   /id="PRO_0000036059"
SQ   SEQUENCE   493 AA;  54762 MW;  11C21DD618318573 CRC64;
     MIFILLTTLL AVGGAQTANI LAVLPTPAYS HHLVYQAYVQ ALADKCHNVT VVKPQLLDYA
     AANKQRCGRI EQIDADMSSQ QYKKLVASSG AFRKRGVVSD ETTVTAENYM GLVEMFRDQF
     DNAHVRSFLA TNRTFDVVVV EAFADYALVF GHLFRPAPVI QIAPGYGLAE NFDAVGAVGR
     HPVHYPNIWR SSSIGNADGA LIEWRLYNEF ELLARRSDAL LKLQFGPNTP TIRQLRNNVQ
     LLLLNLHPVY DNNRPVPPSV QYLGGGLHLT LEPPQRLDIE LEKRLNASVN GTVYVSFGSS
     IDTNSIHAEF LQMLLDTFAK LDNRTVLWKV DDAVAKSVVL PRNVIAQKWF NQRAVLNHRN
     VVAFVTQGGL QSSDEALHAR VPMVCLPMMG DQFHHSAKLE QFGVARALNT VTVSAAQLAL
     AVGDVIADRL AYQLRMTNLL NVVAFDEATP ADKAIKFTER VIRFGHDITR SECSLKSPSA
     NTDYSDYFVR FPL