ID   UDPE_NPVCF              Reviewed;         491 AA.
AC   Q90157;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Ecdysteroid UDP-glucosyltransferase;
DE            EC=2.4.1.-;
DE   Flags: Precursor;
GN   Name=EGT; Synonyms=UGT21A2;
OS   Choristoneura fumiferana nuclear polyhedrosis virus (CfMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=208973;
OH   NCBI_TaxID=7141; Choristoneura fumiferana (Spruce budworm moth) (Archips fumiferana).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7595348; DOI=10.1099/0022-1317-76-10-2447;
RA   Barrett J.W., Krell P.J., Arif B.M.;
RT   "Characterization, sequencing and phylogeny of the ecdysteroid UDP-
RT   glucosyltransferase gene from two distinct nuclear polyhedrosis viruses
RT   isolated from Choristoneura fumiferana.";
RL   J. Gen. Virol. 76:2447-2456(1995).
CC   -!- FUNCTION: Catalyzes the transfer of glucose from UDP-glucose to
CC       ecdysteroids which are insect molting hormones. Expression of egt
CC       interferes with normal insect development and block molting (By
CC       similarity). {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: First observed 9 hours post-infection (p.i.),
CC       peaks around 12 hours p.i.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; AF512031; AAC54601.1; -; Genomic_DNA.
DR   RefSeq; NP_848326.1; NC_004778.3.
DR   SMR; Q90157; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   GeneID; 1482711; -.
DR   KEGG; vg:1482711; -.
DR   Proteomes; UP000204418; Genome.
DR   GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR016224; Ecdysteroid_UDP-Glc_Trfase.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PIRSF; PIRSF000476; Ecdystd_UDP_glucosyltfrase; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   2: Evidence at transcript level;
KW   Glycosyltransferase; Signal; Transferase.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..491
FT                   /note="Ecdysteroid UDP-glucosyltransferase"
FT                   /id="PRO_0000036058"
SQ   SEQUENCE   491 AA;  54499 MW;  AB5699F3B6FCC430 CRC64;
     MASLLIALTL LAADAQTANI LAVLPTPAYS HHAVYKAYVH ALAKNCHNVT AVKPRLLDYA
     LLNECGRIEQ IDADMSLEQY QKLMAGSGAF RKRGVVADET TVTADNYMSL IEMFKDQFDN
     ANVRHFLASN RTFDAVVVEA SADYELVFGH LFRPATVIQI APGYGLAENF DAAGAVARHP
     VHYPNIWRSS FSGEAAGALS EWRLLNEFEL LASQRSNELL KQQFGLDTPT IRQLRDNVQL
     LLLNLHPVYD NNRPVPPSVQ YLGGGLHLSQ APSHKLTAAL ERRLNESVDG AIYVSFGSSI
     DTNSIHAEFI QMLLESFVQL NNYTVLWKVD DTVPASVKLP SNVVTQKWFD QRAVLHHKKV
     VAFVMQAGLQ SSDEALESRV PMVCLPMMGD QFHHARKLQQ FGVARTLDTA VVSAAQLTLA
     IGEVIADAEA YRARIDDLRA VLEHDAAPAE KAVKFTERVI IFKHDMTRPA RTLKTTSANI
     AYSDYFLRFP L