ID   UDPE_NPVLD              Reviewed;         506 AA.
AC   P41713; Q9YMK2;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 2.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Ecdysteroid UDP-glucosyltransferase;
DE            EC=2.4.1.-;
DE   Flags: Precursor;
GN   Name=EGT; Synonyms=UGT21A4; OrderedLocusNames=LdOrf-125;
OS   Lymantria dispar multicapsid nuclear polyhedrosis virus (LdMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=10449;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A21-2;
RX   PubMed=8151299; DOI=10.1099/0022-1317-75-4-829;
RA   Riegel C.I., Lanner-Herrera C., Slavicek J.M.;
RT   "Identification and characterization of the ecdysteroid UDP-
RT   glucosyltransferase gene of the Lymantria dispar multinucleocapsid nuclear
RT   polyhedrosis virus.";
RL   J. Gen. Virol. 75:829-838(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9887315; DOI=10.1006/viro.1998.9469;
RA   Kuzio J., Pearson M.N., Harwood S.H., Funk C.J., Evans J.T., Slavicek J.M.,
RA   Rohrmann G.F.;
RT   "Sequence and analysis of the genome of a baculovirus pathogenic for
RT   Lymantria dispar.";
RL   Virology 253:17-34(1999).
CC   -!- FUNCTION: Catalyzes the transfer of glucose from UDP-glucose to
CC       ecdysteroids which are insect molting hormones. Expression of egt
CC       interferes with normal insect development and block molting (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC70311.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U04321; AAA18788.1; -; Unassigned_DNA.
DR   EMBL; AF081810; AAC70311.1; ALT_INIT; Genomic_DNA.
DR   PIR; T30475; T30475.
DR   RefSeq; NP_047762.1; NC_001973.1.
DR   SMR; P41713; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   GeneID; 1488529; -.
DR   KEGG; vg:1488529; -.
DR   Proteomes; UP000203997; Genome.
DR   GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR016224; Ecdysteroid_UDP-Glc_Trfase.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PIRSF; PIRSF000476; Ecdystd_UDP_glucosyltfrase; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Signal; Transferase.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..506
FT                   /note="Ecdysteroid UDP-glucosyltransferase"
FT                   /id="PRO_0000036060"
FT   CONFLICT        483..506
FT                   /note="DLLAPLLSVSLMSHLHSLIRMFVW -> TCWRPC (in Ref. 1;
FT                   AAA18788)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   506 AA;  57125 MW;  9661C231965947C9 CRC64;
     MTAYLIVFCL CCWSAARSAN ILAYFPTPSY SHQLVFRAYV ELLAERGHAV TVIRPLTRVD
     FNRNAGNLTT IDLDGDGLLL LMKASTTHRK RGIVADTDTV TADNYEALVR MVDRQIHSEP
     FQRHLKSARR GYDLLVVEAF VDYALIASHL FGDVPVVQIS SGHATAENFE TMGATSRHPR
     YYPNLWRFNF GPLSVWDGVR ELYTELRLQR EFGLLADRQD ALLKRRFGPE APGLRELRSR
     VRLLFVNVHS VFDNNRPVPP SVQYLGGLHL HDRRAEPLSE AVARFLDESR RGVVYVSFGS
     GLATEDMDAD MAAALLDAFK MMPYDVLWKH DGRVDGLTIP ANVFVQKWFA QFEVLQHKNV
     KAFVTQAGVQ STDEAVENLV PLVGVPLMGD QAFNAHRYVE LGIGVALDAT RLTAADLARA
     VEQVTSDRAY RENLERLRRL LRHQCASPTH KAVWYTEHAL RRDGDALKTK AANVDYAEYC
     MSDLLAPLLS VSLMSHLHSL IRMFVW