ID   UDPE_NPVMB              Reviewed;         528 AA.
AC   Q83140;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   23-FEB-2022, entry version 56.
DE   RecName: Full=Ecdysteroid UDP-glucosyltransferase;
DE            EC=2.4.1.-;
DE   Flags: Precursor;
GN   Name=EGT; Synonyms=UGT21A5;
OS   Mamestra brassicae nuclear polyhedrosis virus (MbNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=78219;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Oxford;
RX   PubMed=8922482; DOI=10.1099/0022-1317-77-11-2865;
RA   Clarke E.E., Tristem M., Cory J.S., O'Reilly D.R.;
RT   "Characterization of the ecdysteroid UDP-glucosyltransferase gene from
RT   Mamestra brassicae nucleopolyhedrovirus.";
RL   J. Gen. Virol. 77:2865-2871(1996).
CC   -!- FUNCTION: Catalyzes the transfer of glucose from UDP-glucose to
CC       ecdysteroids which are insect molting hormones. Expression of egt
CC       interferes with normal insect development and block molting (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; U41999; AAB03658.1; -; Genomic_DNA.
DR   SMR; Q83140; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   PRIDE; Q83140; -.
DR   GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR016224; Ecdysteroid_UDP-Glc_Trfase.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PIRSF; PIRSF000476; Ecdystd_UDP_glucosyltfrase; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Signal; Transferase.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..528
FT                   /note="Ecdysteroid UDP-glucosyltransferase"
FT                   /id="PRO_0000036061"
SQ   SEQUENCE   528 AA;  61013 MW;  A1E9A7DABC1AE4B7 CRC64;
     MGHLHIVHWR LTMNGAIAAL FLCLVMVHQQ HAVRILAVFP TPAYSHHSVF KVYIEALAER
     GHDVVVIKST DRINYANRNG LRGNVSEIDA SLSQEYYGRL MRHAGVFRKR GIVADSSTVT
     AHNYMGLVRM MSDQFDLPIV KSFIEEAHKH KFDLLITEAY IDYPLVFSHL FGDLPVVQIS
     SGYAVAENFE TMGAVSRHPV YYPNLWRDKF SGLNVWKQSM KCTLSWRYRM NLVNWPDEQN
     ALLKRQFGES TPTIQELRNR VELLFVNTHA IFDNNRPVPP SVQYLGALHL HDKRPDSMYG
     MVREFLDNAT TGAIYVSFGS AISSEDMEPE FIEMLLRVFE KLPYSILWKY DGYMNRMPAN
     VFVQSWFEQY NLLHHKNVRA FVTQGGVQST DEAVEAIVPM VGMPMMGDQA YNMNKIVELG
     LGKVVDTVRV NAEQLIEAIV DVAESPKYRK RLRELRHMIH HQPMTPLQKA VWYTEHVIES
     RRRVVPTMLK TRAANVNYSD YIMSYVFVPF IMFTVMNHLR QLLKMNMV