ID   UDPE_NPVOP              Reviewed;         489 AA.
AC   Q65363; O10275;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Ecdysteroid UDP-glucosyltransferase;
DE            EC=2.4.1.-;
DE   Flags: Precursor;
GN   Name=EGT; Synonyms=UGT21A6; ORFNames=ORF14;
OS   Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=262177;
OH   NCBI_TaxID=33414; Orgyia pseudotsugata (Douglas-fir tussock moth).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9126251; DOI=10.1006/viro.1997.8448;
RA   Ahrens C.H., Russell R.R., Funk C.J., Evans J., Harwood S., Rohrmann G.F.;
RT   "The sequence of the Orgyia pseudotsugata multinucleocapsid nuclear
RT   polyhedrosis virus genome.";
RL   Virology 229:381-399(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-293.
RX   PubMed=8249294; DOI=10.1006/viro.1993.1647;
RA   Pearson M.N., Bjornson R.M., Ahrens C.H., Rohrmann G.F.;
RT   "Identification and characterization of a putative origin of DNA
RT   replication in the genome of a baculovirus pathogenic for Orgyia
RT   pseudotsugata.";
RL   Virology 197:715-725(1993).
CC   -!- FUNCTION: Catalyzes the transfer of glucose from UDP-glucose to
CC       ecdysteroids which are insect molting hormones. Expression of egt
CC       interferes with normal insect development and block molting (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; U75930; AAC59013.1; -; Genomic_DNA.
DR   EMBL; D17353; BAA04172.1; -; Genomic_DNA.
DR   RefSeq; NP_046170.1; NC_001875.2.
DR   SMR; Q65363; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   GeneID; 912033; -.
DR   KEGG; vg:912033; -.
DR   Proteomes; UP000009248; Genome.
DR   GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR016224; Ecdysteroid_UDP-Glc_Trfase.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PIRSF; PIRSF000476; Ecdystd_UDP_glucosyltfrase; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Signal; Transferase.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..489
FT                   /note="Ecdysteroid UDP-glucosyltransferase"
FT                   /id="PRO_0000036062"
SQ   SEQUENCE   489 AA;  54523 MW;  F084EF8CA1E26D43 CRC64;
     MVFLIIALTL LATGARAASI LAVLPTPAYS HHVVYRAYVH ALVKNCHNVT VIKPQLLDYA
     VQDECGRVEQ IDADMSAQQY KKLVASSGVF RKRGVVADET TVTADNYMGL IEMFKDQFDN
     ANVRRFLSTN RTFDAVVVEA FADYALVFGH LFRPAPVIQI APGYGLAENF ERRRAVARHP
     LHYPTFGAAA LTRRGGALSE WRLLNEFELL ARRSDELLKQ QFGKSTPTIR QLRDNVQLLL
     LNLHPVYDNN RPVPPSVQYL GGGLHLAQAL PQRLDAPLER RLNESVDGAV YVSFGSGIDT
     NSIHAEFLQM LLDTFANLNN YTVLWKVDDA VAASVALPRN VLAQKWFSQT AVLRHKNVVA
     FVTQAGLQSS DEALQARVPM VCLPMMGDQF HHARKLQQFG VARALDTAAV SAPQLQLAIR
     EVIADGEAYR ARIDKLRAVV EHDAAPDEKA VKFTERVIKF NNDVNWPARS LKTTAANMAY
     SDYFVRFPL