ID   UDPE_NPVSL              Reviewed;         515 AA.
AC   Q88168;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   23-FEB-2022, entry version 51.
DE   RecName: Full=Ecdysteroid UDP-glucosyltransferase;
DE            EC=2.4.1.-;
DE   Flags: Precursor;
GN   Name=EGT; Synonyms=UGT21A7;
OS   Spodoptera littoralis nuclear polyhedrosis virus (SlNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=10456;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=E15;
RX   PubMed=8808334; DOI=10.1007/bf01701661;
RA   Faktor O., Toister-Achituv M., Kamensky B.;
RT   "Identification and nucleotide sequence of an ecdysteroid UDP-
RT   glucosyltransferase gene of Spodoptera littoralis multicapsid nuclear
RT   polyhedrosis virus.";
RL   Virus Genes 11:47-52(1995).
CC   -!- FUNCTION: Catalyzes the transfer of glucose from UDP-glucose to
CC       ecdysteroids which are insect molting hormones. Expression of egt
CC       interferes with normal insect development and block molting (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; X84701; CAA59174.1; -; Genomic_DNA.
DR   PIR; S52453; S52453.
DR   SMR; Q88168; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR016224; Ecdysteroid_UDP-Glc_Trfase.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PIRSF; PIRSF000476; Ecdystd_UDP_glucosyltfrase; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Signal; Transferase.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..515
FT                   /note="Ecdysteroid UDP-glucosyltransferase"
FT                   /id="PRO_0000036063"
SQ   SEQUENCE   515 AA;  59026 MW;  16D83D1CBB4B58F5 CRC64;
     MKMIILVVSL HVLRNSAAVR VLCMFPTPSY SHQTVFDVYV NALLRRGHSL VVISPKIHNH
     NHGHRHHRHE NLTEIDVGSV TNNFFKRLLQ DSKVSRKRGI VSDSSTVTRV NYLGLARMIS
     AQFEHEQVKR LLRSNQTFDV IVIEAFVSYP LILSYFFKDT PVIQISSGHG TAENFETMGA
     VARHPVYYPN MWRDRFKGLS VWQTVRQVFT EIRLYMEFSQ LDADQSAMMK RQFGSKVPDV
     DALRKNVHMM FVNTHPVFDT NRPVPSNVQY LGGIHIDPAV TSVADEIDND LAEFLENSTM
     GVVYVSLGSS VRASDMDSNM LNVFVETFRS IPYRVLWKVD KSDKIFDNIP SNVLIQRWFP
     QRRVLKHRNV KVFITQGGVQ STDEAIDAGV PMFGVPIMGD QFYNVYMYET YGIGRGVDTL
     TVDARQLTEI VMDVADNEKY KNGTLWLRDA IMDQPMRPLE KAVWYTEHVA RRKGAKKHLG
     TRAANVTYSK YAMFDLILPM LITIFSTYLQ KILSI