ID   UDP_HAEIN               Reviewed;         252 AA.
AC   P43770;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2003, sequence version 2.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Uridine phosphorylase;
DE            Short=UPase;
DE            Short=UrdPase;
DE            EC=2.4.2.3;
GN   Name=udp; OrderedLocusNames=HI_0280;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Catalyzes the reversible phosphorylytic cleavage of uridine
CC       and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The
CC       produced molecules are then utilized as carbon and energy sources or in
CC       the rescue of pyrimidine bases for nucleotide synthesis (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=phosphate + uridine = alpha-D-ribose 1-phosphate + uracil;
CC         Xref=Rhea:RHEA:24388, ChEBI:CHEBI:16704, ChEBI:CHEBI:17568,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.3;
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway;
CC       uracil from uridine (phosphorylase route): step 1/1.
CC   -!- SUBUNIT: Homohexamer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PNP/UDP phosphorylase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC21943.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L42023; AAC21943.1; ALT_INIT; Genomic_DNA.
DR   PIR; C64059; C64059.
DR   RefSeq; NP_438448.2; NC_000907.1.
DR   RefSeq; WP_010868970.1; NC_000907.1.
DR   AlphaFoldDB; P43770; -.
DR   SMR; P43770; -.
DR   STRING; 71421.HI_0280; -.
DR   EnsemblBacteria; AAC21943; AAC21943; HI_0280.
DR   KEGG; hin:HI_0280; -.
DR   PATRIC; fig|71421.8.peg.296; -.
DR   eggNOG; COG2820; Bacteria.
DR   HOGENOM; CLU_068457_0_0_6; -.
DR   PhylomeDB; P43770; -.
DR   BioCyc; HINF71421:G1GJ1-299-MON; -.
DR   UniPathway; UPA00574; UER00633.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004850; F:uridine phosphorylase activity; IBA:GO_Central.
DR   GO; GO:0009166; P:nucleotide catabolic process; IEA:InterPro.
DR   GO; GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006218; P:uridine catabolic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.1580; -; 1.
DR   InterPro; IPR018016; Nucleoside_phosphorylase_CS.
DR   InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR   InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR   InterPro; IPR010058; Uridine_phosphorylase.
DR   Pfam; PF01048; PNP_UDP_1; 1.
DR   SUPFAM; SSF53167; SSF53167; 1.
DR   TIGRFAMs; TIGR01718; Uridine-psphlse; 1.
DR   PROSITE; PS01232; PNP_UDP_1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Glycosyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..252
FT                   /note="Uridine phosphorylase"
FT                   /id="PRO_0000063186"
SQ   SEQUENCE   252 AA;  27254 MW;  30A007A6A764DEF6 CRC64;
     MSGVFHLNLT KAQLKGATLA IVPGDPARSE RIAKQLDNPE FLTSTREFTS WLGYINGQPI
     VVCSTGIGGP STSICVEELA QLGVRTFLRI GTTGAIQPHI NVGDVLITTA AVRLDGASHH
     FVPLEYPAVA NFECTTALYN AAKAKGIEPY VGVTVSSDTF YPGQERYDTY SGKVYRNYQG
     LLKQWQDLNV MNYEMESSTL FTMCSALGLR AGMVAGVIVN RTQQEIPNEA TIKQTEEKAV
     SVVITAAQAL LS