ID   UDP_KLEPN               Reviewed;         279 AA.
AC   P52671;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Uridine phosphorylase;
DE            Short=UPase;
DE            Short=UrdPase;
DE            EC=2.4.2.3;
GN   Name=udp;
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LF1202;
RX   PubMed=8534998; DOI=10.1271/bbb.59.1987;
RA   Takehara M., Ling F., Izawa S., Inoue Y., Kimura A.;
RT   "Molecular cloning and nucleotide sequence of purine nucleoside
RT   phosphorylase and uridine phosphorylase genes from Klebsiella sp.";
RL   Biosci. Biotechnol. Biochem. 59:1987-1990(1995).
CC   -!- FUNCTION: Catalyzes the reversible phosphorylytic cleavage of uridine
CC       and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The
CC       produced molecules are then utilized as carbon and energy sources or in
CC       the rescue of pyrimidine bases for nucleotide synthesis (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=phosphate + uridine = alpha-D-ribose 1-phosphate + uracil;
CC         Xref=Rhea:RHEA:24388, ChEBI:CHEBI:16704, ChEBI:CHEBI:17568,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.3;
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway;
CC       uracil from uridine (phosphorylase route): step 1/1.
CC   -!- SUBUNIT: Homohexamer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PNP/UDP phosphorylase family. {ECO:0000305}.
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DR   EMBL; X87882; CAA61137.1; -; Genomic_DNA.
DR   AlphaFoldDB; P52671; -.
DR   SMR; P52671; -.
DR   UniPathway; UPA00574; UER00633.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004850; F:uridine phosphorylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009164; P:nucleoside catabolic process; IEA:UniProt.
DR   GO; GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.1580; -; 1.
DR   InterPro; IPR018016; Nucleoside_phosphorylase_CS.
DR   InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR   InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR   Pfam; PF01048; PNP_UDP_1; 1.
DR   SUPFAM; SSF53167; SSF53167; 1.
DR   PROSITE; PS01232; PNP_UDP_1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Glycosyltransferase; Transferase.
FT   CHAIN           1..279
FT                   /note="Uridine phosphorylase"
FT                   /id="PRO_0000063188"
SQ   SEQUENCE   279 AA;  30274 MW;  C650E02F10FA327C CRC64;
     MSKSDVFHLG LTKNDLQGAT LAIVPGDPER VEKIAALMDK PVKLASHREF TSWRAELDGK
     SLIVCSTGIG GPSTSIRVEE LASTLGVDSR TLTPRIGTTG AIQPHINVGD VLVTTASVRL
     DGASLHFAPM EFPAVETSTA TRAGEARKSI GATTIGVTAS DTFYPGQERY DTSGRERNSR
     SHIVRTLSIL YQQQTYDTYS RVERFKGSME EWQAMGVMNY EMESATVLTM CASQGLRAGM
     VAGVIVNRTQ QEIPNAETMK STESQFAVKI VVEAARRLL