UEHC_RUEPO
ID UEHC_RUEPO Reviewed; 428 AA.
AC Q5LUA9;
DT 20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Ectoine/5-hydroxyectoine TRAP transporter large permease protein UehC {ECO:0000305};
DE AltName: Full=Uptake of ectoine and hydroxyectoine protein C {ECO:0000305};
GN Name=uehC {ECO:0000303|PubMed:19362561};
GN OrderedLocusNames=SPO1145 {ECO:0000312|EMBL:AAV94445.1};
OS Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter
OS pomeroyi).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Ruegeria.
OX NCBI_TaxID=246200;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700808 / DSM 15171 / DSS-3;
RX PubMed=15602564; DOI=10.1038/nature03170;
RA Moran M.A., Buchan A., Gonzalez J.M., Heidelberg J.F., Whitman W.B.,
RA Kiene R.P., Henriksen J.R., King G.M., Belas R., Fuqua C., Brinkac L.M.,
RA Lewis M., Johri S., Weaver B., Pai G., Eisen J.A., Rahe E., Sheldon W.M.,
RA Ye W., Miller T.R., Carlton J., Rasko D.A., Paulsen I.T., Ren Q.,
RA Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S., Madupu R.,
RA Nelson W.C., Sullivan S.A., Rosovitz M.J., Haft D.H., Selengut J., Ward N.;
RT "Genome sequence of Silicibacter pomeroyi reveals adaptations to the marine
RT environment.";
RL Nature 432:910-913(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 700808 / DSM 15171 / DSS-3;
RX PubMed=25780504; DOI=10.1186/1944-3277-9-11;
RA Rivers A.R., Smith C.B., Moran M.A.;
RT "An updated genome annotation for the model marine bacterium Ruegeria
RT pomeroyi DSS-3.";
RL Stand. Genomic Sci. 9:11-11(2014).
RN [3]
RP PROBABLE FUNCTION, AND SUBUNIT.
RC STRAIN=ATCC 700808 / DSM 15171 / DSS-3;
RX PubMed=19362561; DOI=10.1016/j.jmb.2009.03.077;
RA Lecher J., Pittelkow M., Zobel S., Bursy J., Bonig T., Smits S.H.,
RA Schmitt L., Bremer E.;
RT "The crystal structure of UehA in complex with ectoine-A comparison with
RT other TRAP-T binding proteins.";
RL J. Mol. Biol. 389:58-73(2009).
CC -!- FUNCTION: Part of the tripartite ATP-independent periplasmic (TRAP)
CC transport system UehABC, which imports both ectoine and 5-
CC hydroxyectoine as nutrients, and not as osmoprotectants.
CC {ECO:0000305|PubMed:19362561}.
CC -!- SUBUNIT: The complex comprises the extracytoplasmic solute receptor
CC protein UehA, and the two transmembrane proteins UehB and UehC.
CC {ECO:0000305|PubMed:19362561}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- MISCELLANEOUS: Transport is enhanced in cells that are grown in the
CC presence of ectoine, but not by high-salinity media.
CC {ECO:0000269|PubMed:19362561}.
CC -!- SIMILARITY: Belongs to the TRAP transporter large permease family.
CC {ECO:0000305}.
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DR EMBL; CP000031; AAV94445.1; -; Genomic_DNA.
DR RefSeq; WP_011046892.1; NC_003911.12.
DR AlphaFoldDB; Q5LUA9; -.
DR STRING; 246200.SPO1145; -.
DR EnsemblBacteria; AAV94445; AAV94445; SPO1145.
DR KEGG; sil:SPO1145; -.
DR eggNOG; COG1593; Bacteria.
DR HOGENOM; CLU_019824_4_1_5; -.
DR OMA; AFSWYIS; -.
DR OrthoDB; 903568at2; -.
DR Proteomes; UP000001023; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR010656; DctM.
DR InterPro; IPR004681; TRAP_DctM.
DR PANTHER; PTHR33362; PTHR33362; 1.
DR Pfam; PF06808; DctM; 1.
DR PIRSF; PIRSF006066; HI0050; 1.
DR TIGRFAMs; TIGR00786; dctM; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..428
FT /note="Ectoine/5-hydroxyectoine TRAP transporter large
FT permease protein UehC"
FT /id="PRO_0000435357"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 400..420
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 428 AA; 45174 MW; 50F146983028149E CRC64;
MAATIFLTMI VLLLLGFPMM IPLIAGAFIG FLMLFGDLAR TETMVQQMLA GIRPASLIAV
PMFIFAADIM TRGQSAGRLI NVVMAYVGHI RGGLAISTAA ACTMFGAVSG STQATVVAIG
SPLRPRMLKA GYKDSFVLAL IVNASDIAFL IPPSIGMIIY GVVSSTSIAE LFIAGIGPGL
LILVLFSAYA YIYAVRNDVP TEPRASWAER ARTMRQALWP MGFPVIIIGG IYGGVFSPTE
AAAACVLYAL VLEVLVFRSM SLADVYDTAK STGLITAIVF ILVGAGAAFS WVISFAQVPQ
QILGAIGIAE MGPIGVLFVI SIAFFIGCMF VDPIVVILVL VPVFAPVVKS VGLDPVLVGT
IITLQVAIGS ATPPFGCDIF TAIAVFKRPY AEVVRGTPPF ILMLLGVSVA LIFFPQIALF
LRDLAFSK
