UFC1_ARATH
ID UFC1_ARATH Reviewed; 174 AA.
AC Q9SXC8; Q8H0X8;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Ubiquitin-fold modifier-conjugating enzyme 1;
DE AltName: Full=Ufm1-conjugating enzyme 1;
GN OrderedLocusNames=At1g27530; ORFNames=T17H3.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: E2-like enzyme which forms an intermediate with UFM1 via a
CC thioester linkage. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UFC1
CC subfamily. {ECO:0000305}.
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DR EMBL; AC005916; AAD45991.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30842.1; -; Genomic_DNA.
DR EMBL; AY054632; AAK96823.1; -; mRNA.
DR EMBL; BT001180; AAN65067.1; -; mRNA.
DR EMBL; AY085696; AAM62915.1; -; mRNA.
DR PIR; D86400; D86400.
DR RefSeq; NP_564289.1; NM_102517.5.
DR AlphaFoldDB; Q9SXC8; -.
DR SMR; Q9SXC8; -.
DR BioGRID; 24879; 2.
DR STRING; 3702.AT1G27530.1; -.
DR iPTMnet; Q9SXC8; -.
DR MetOSite; Q9SXC8; -.
DR PaxDb; Q9SXC8; -.
DR PRIDE; Q9SXC8; -.
DR ProteomicsDB; 233031; -.
DR DNASU; 839644; -.
DR EnsemblPlants; AT1G27530.1; AT1G27530.1; AT1G27530.
DR GeneID; 839644; -.
DR Gramene; AT1G27530.1; AT1G27530.1; AT1G27530.
DR KEGG; ath:AT1G27530; -.
DR Araport; AT1G27530; -.
DR TAIR; locus:2196879; AT1G27530.
DR eggNOG; KOG3357; Eukaryota.
DR HOGENOM; CLU_101170_0_0_1; -.
DR InParanoid; Q9SXC8; -.
DR OMA; IKYVQNN; -.
DR OrthoDB; 1339876at2759; -.
DR PhylomeDB; Q9SXC8; -.
DR PRO; PR:Q9SXC8; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SXC8; baseline and differential.
DR Genevisible; Q9SXC8; AT.
DR GO; GO:0061657; F:UFM1 conjugating enzyme activity; IEA:InterPro.
DR GO; GO:0071568; F:UFM1 transferase activity; IBA:GO_Central.
DR GO; GO:1990592; P:protein K69-linked ufmylation; IBA:GO_Central.
DR Gene3D; 3.10.110.10; -; 1.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR014806; Ufc1.
DR PANTHER; PTHR12921; PTHR12921; 1.
DR Pfam; PF08694; UFC1; 1.
DR PIRSF; PIRSF008716; DUF1782; 1.
DR SUPFAM; SSF54495; SSF54495; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..174
FT /note="Ubiquitin-fold modifier-conjugating enzyme 1"
FT /id="PRO_0000391980"
FT ACT_SITE 119
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000250"
FT CONFLICT 169
FT /note="A -> V (in Ref. 3; AAN65067)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 174 AA; 19611 MW; AF17805A992D9ED6 CRC64;
MEGWDPNTKS TLTRIPLLTT KAGPRDGAAW TQRLKEEYKS LIAYTQMNKS NDNDWFRISA
SNPEGTRWTG KCWYVHNLLK YEFDLQFDIP ITYPATAPEL ELPEIDGKTQ KMYRGGKICL
TVHFKPLWAK NCPRFGIAHA LCLGLAPWLA AEIPILVDSG AIKHKDDAAT SAES
