ID   UFC1_BOVIN              Reviewed;         167 AA.
AC   Q5E953; Q3SZ50;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Ubiquitin-fold modifier-conjugating enzyme 1 {ECO:0000305};
DE            Short=Ufm1-conjugating enzyme 1 {ECO:0000250|UniProtKB:Q9Y3C8};
GN   Name=UFC1 {ECO:0000250|UniProtKB:Q9Y3C8};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: E1-like enzyme which specifically catalyzes the second step
CC       in ufmylation. Accepts the ubiquitin-like modifier UFM1 from the E1
CC       enzyme UBA5 and forms an intermediate with UFM1 via a thioester
CC       linkage. Ufmylation is involved in reticulophagy (also called ER-phagy)
CC       induced in response to endoplasmic reticulum stress.
CC       {ECO:0000250|UniProtKB:Q9Y3C8}.
CC   -!- SUBUNIT: Interacts with UBA5 (via C-terminus). Interacts with UFL1.
CC       Interacts with KIRREL3. Interacts with UFM1.
CC       {ECO:0000250|UniProtKB:Q9Y3C8}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UFC1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BT021067; AAX09084.1; -; mRNA.
DR   EMBL; BC103142; AAI03143.1; -; mRNA.
DR   RefSeq; NP_001015663.1; NM_001015663.1.
DR   RefSeq; XP_005203588.1; XM_005203531.3.
DR   RefSeq; XP_010801073.1; XM_010802771.2.
DR   AlphaFoldDB; Q5E953; -.
DR   BMRB; Q5E953; -.
DR   SMR; Q5E953; -.
DR   STRING; 9913.ENSBTAP00000028928; -.
DR   PaxDb; Q5E953; -.
DR   PRIDE; Q5E953; -.
DR   DNASU; 537221; -.
DR   Ensembl; ENSBTAT00000028928; ENSBTAP00000028928; ENSBTAG00000021705.
DR   GeneID; 537221; -.
DR   KEGG; bta:537221; -.
DR   CTD; 51506; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021705; -.
DR   VGNC; VGNC:36644; UFC1.
DR   eggNOG; KOG3357; Eukaryota.
DR   GeneTree; ENSGT00390000008196; -.
DR   HOGENOM; CLU_101170_0_0_1; -.
DR   InParanoid; Q5E953; -.
DR   OMA; IKYVQNN; -.
DR   OrthoDB; 1339876at2759; -.
DR   TreeFam; TF313587; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000021705; Expressed in thyroid gland and 106 other tissues.
DR   ExpressionAtlas; Q5E953; baseline and differential.
DR   GO; GO:0061657; F:UFM1 conjugating enzyme activity; ISS:UniProtKB.
DR   GO; GO:0071568; F:UFM1 transferase activity; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; ISS:UniProtKB.
DR   GO; GO:1990592; P:protein K69-linked ufmylation; ISS:UniProtKB.
DR   GO; GO:0071569; P:protein ufmylation; ISS:UniProtKB.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; ISS:UniProtKB.
DR   GO; GO:0061709; P:reticulophagy; ISS:UniProtKB.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   InterPro; IPR014806; Ufc1.
DR   PANTHER; PTHR12921; PTHR12921; 1.
DR   Pfam; PF08694; UFC1; 1.
DR   PIRSF; PIRSF008716; DUF1782; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..167
FT                   /note="Ubiquitin-fold modifier-conjugating enzyme 1"
FT                   /id="PRO_0000082612"
FT   ACT_SITE        116
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y3C8"
SQ   SEQUENCE   167 AA;  19431 MW;  166429187DC43E14 CRC64;
     MADEATRRVV SEIPVLKTNA GPRDRELWVQ RLKEEYQSLI RYVENNKNAD NDWFRLESNK
     EGTRWFGKCW YIHDLLKYEF DIEFDIPITY PTTAPEIAVP ELDGKTAKMY RGGKICLTDH
     FKPLWARNVP KFGLAHLMAL GLGPWLAVEI PDLIQKGVIQ HKEKCSQ