ID   UFC1_BRUMA              Reviewed;         165 AA.
AC   A8Q8J2;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Ubiquitin-fold modifier-conjugating enzyme 1;
DE   AltName: Full=Ufm1-conjugating enzyme 1;
GN   ORFNames=Bm1_46190;
OS   Brugia malayi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17885136; DOI=10.1126/science.1145406;
RA   Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA   Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA   Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA   Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA   Pop M., White O., Barton G.J., Carlow C.K.S., Crawford M.J., Daub J.,
RA   Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA   Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.-W.,
RA   Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA   McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA   Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA   Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA   Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA   Blaxter M.L., Scott A.L.;
RT   "Draft genome of the filarial nematode parasite Brugia malayi.";
RL   Science 317:1756-1760(2007).
CC   -!- FUNCTION: E2-like enzyme which forms an intermediate with UFM1 via a
CC       thioester linkage. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UFC1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; DS239419; EDP30455.1; -; Genomic_DNA.
DR   RefSeq; XP_001900700.1; XM_001900665.1.
DR   AlphaFoldDB; A8Q8J2; -.
DR   SMR; A8Q8J2; -.
DR   STRING; 6279.A8Q8J2; -.
DR   PRIDE; A8Q8J2; -.
DR   EnsemblMetazoa; Bm2685.1; Bm2685.1; WBGene00222946.
DR   GeneID; 6104120; -.
DR   KEGG; bmy:BM_BM2685; -.
DR   WBParaSite; Bm2685.1; Bm2685.1; WBGene00222946.
DR   CTD; 6104120; -.
DR   WormBase; Bm2685; BM30868; WBGene00222946; Bma-ufc-1.
DR   HOGENOM; CLU_101170_0_0_1; -.
DR   InParanoid; A8Q8J2; -.
DR   OMA; IKYVQNN; -.
DR   OrthoDB; 1339876at2759; -.
DR   Proteomes; UP000006672; Unassembled WGS sequence.
DR   GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IEA:EnsemblMetazoa.
DR   GO; GO:0061657; F:UFM1 conjugating enzyme activity; IEA:InterPro.
DR   GO; GO:0071569; P:protein ufmylation; IEA:InterPro.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   InterPro; IPR014806; Ufc1.
DR   PANTHER; PTHR12921; PTHR12921; 1.
DR   Pfam; PF08694; UFC1; 1.
DR   PIRSF; PIRSF008716; DUF1782; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..165
FT                   /note="Ubiquitin-fold modifier-conjugating enzyme 1"
FT                   /id="PRO_0000391962"
FT   ACT_SITE        117
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   165 AA;  18848 MW;  21AFADDC654A2AC6 CRC64;
     MELSESTKKA LKAIPLMRTK AGPRDGDSWV QRLKEEYEAL IAFINNNKAA DLDWFRLESN
     SDGTRWFGKC WHYHNMLRYE FDVEFDIPVT YPTTAPEIAL PELDGKTAKM YRGGRICLSD
     HFKPLWARNV PKFGIAQAFS LGLGPWLAVE VPDLVDRGMI QPKTA