UFC1_CAEEL
ID UFC1_CAEEL Reviewed; 162 AA.
AC Q03598;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Ubiquitin-fold modifier-conjugating enzyme 1;
DE Short=Ufm1-conjugating enzyme 1;
GN Name=ufc-1 {ECO:0000312|WormBase:C40H1.6};
GN ORFNames=C40H1.6 {ECO:0000312|WormBase:C40H1.6};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION, INTERACTION WITH UBA-5, AND TISSUE SPECIFICITY.
RX PubMed=23449979; DOI=10.1074/jbc.m113.458000;
RA Hertel P., Daniel J., Stegehake D., Vaupel H., Kailayangiri S., Gruel C.,
RA Woltersdorf C., Liebau E.;
RT "The ubiquitin-fold modifier 1 (Ufm1) cascade of Caenorhabditis elegans.";
RL J. Biol. Chem. 288:10661-10671(2013).
CC -!- FUNCTION: E2-like enzyme which forms an intermediate with ufm-1
CC (PubMed:23449979). The intermediate is formed via a thioester linkage
CC (By similarity). {ECO:0000250|UniProtKB:Q9Y3C8,
CC ECO:0000269|PubMed:23449979}.
CC -!- SUBUNIT: Interacts with uba-5. {ECO:0000269|PubMed:23449979}.
CC -!- TISSUE SPECIFICITY: Expressed in the intestine.
CC {ECO:0000269|PubMed:23449979}.
CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UFC1
CC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z19154; CAA79557.1; -; Genomic_DNA.
DR PIR; S28301; S28301.
DR RefSeq; NP_499055.1; NM_066654.4.
DR AlphaFoldDB; Q03598; -.
DR SMR; Q03598; -.
DR BioGRID; 41511; 12.
DR DIP; DIP-26698N; -.
DR IntAct; Q03598; 2.
DR STRING; 6239.C40H1.6.2; -.
DR EPD; Q03598; -.
DR PaxDb; Q03598; -.
DR PeptideAtlas; Q03598; -.
DR EnsemblMetazoa; C40H1.6.1; C40H1.6.1; WBGene00008041.
DR GeneID; 176313; -.
DR KEGG; cel:CELE_C40H1.6; -.
DR UCSC; C40H1.6; c. elegans.
DR CTD; 176313; -.
DR WormBase; C40H1.6; CE00114; WBGene00008041; ufc-1.
DR eggNOG; KOG3357; Eukaryota.
DR GeneTree; ENSGT00390000008196; -.
DR HOGENOM; CLU_101170_0_0_1; -.
DR InParanoid; Q03598; -.
DR OMA; IKYVQNN; -.
DR OrthoDB; 1339876at2759; -.
DR PhylomeDB; Q03598; -.
DR PRO; PR:Q03598; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00008041; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; HDA:WormBase.
DR GO; GO:0055120; C:striated muscle dense body; HDA:WormBase.
DR GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IPI:UniProtKB.
DR GO; GO:0061657; F:UFM1 conjugating enzyme activity; IEA:InterPro.
DR GO; GO:0071568; F:UFM1 transferase activity; IBA:GO_Central.
DR GO; GO:1990592; P:protein K69-linked ufmylation; IBA:GO_Central.
DR Gene3D; 3.10.110.10; -; 1.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR014806; Ufc1.
DR PANTHER; PTHR12921; PTHR12921; 1.
DR Pfam; PF08694; UFC1; 1.
DR PIRSF; PIRSF008716; DUF1782; 1.
DR SUPFAM; SSF54495; SSF54495; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..162
FT /note="Ubiquitin-fold modifier-conjugating enzyme 1"
FT /id="PRO_0000082616"
FT ACT_SITE 115
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3C8"
SQ SEQUENCE 162 AA; 18537 MW; 8DC03CE3BCE79D55 CRC64;
MDDATKSSLK AIPLCKTKAS PRDGDLWIER LKEEYEAIIA AVQNNKDCDR DWFQLESNER
GTKWFGKCWY FHNMVKYEFD VEFDIPITYP VTAPEIALPE LDGKTAKMYR GGKICLSEHF
KPLWARNTPK FGIAHAFALG LGPWMAVEIP DLIEKGLIQP KA
