ID   UFC1_CULQU              Reviewed;         169 AA.
AC   B0WVC4;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Ubiquitin-fold modifier-conjugating enzyme 1;
DE   AltName: Full=Ufm1-conjugating enzyme 1;
GN   ORFNames=CPIJ011320;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB;
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: E2-like enzyme which forms an intermediate with UFM1 via a
CC       thioester linkage. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UFC1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; DS232122; EDS35524.1; -; Genomic_DNA.
DR   RefSeq; XP_001861346.1; XM_001861311.1.
DR   AlphaFoldDB; B0WVC4; -.
DR   SMR; B0WVC4; -.
DR   STRING; 7176.CPIJ011320-PA; -.
DR   EnsemblMetazoa; XM_001861311.2; XP_001861346.1; LOC6043725.
DR   GeneID; 6043725; -.
DR   KEGG; cqu:CpipJ_CPIJ011320; -.
DR   VEuPathDB; VectorBase:CPIJ011320; -.
DR   VEuPathDB; VectorBase:CQUJHB005841; -.
DR   eggNOG; KOG3357; Eukaryota.
DR   HOGENOM; CLU_101170_0_0_1; -.
DR   InParanoid; B0WVC4; -.
DR   OMA; IKYVQNN; -.
DR   OrthoDB; 1339876at2759; -.
DR   PhylomeDB; B0WVC4; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0061657; F:UFM1 conjugating enzyme activity; IEA:InterPro.
DR   GO; GO:0071569; P:protein ufmylation; IEA:InterPro.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   InterPro; IPR014806; Ufc1.
DR   PANTHER; PTHR12921; PTHR12921; 1.
DR   Pfam; PF08694; UFC1; 1.
DR   PIRSF; PIRSF008716; DUF1782; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..169
FT                   /note="Ubiquitin-fold modifier-conjugating enzyme 1"
FT                   /id="PRO_0000391966"
FT   ACT_SITE        116
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   169 AA;  19193 MW;  3BD1C39380B70D5A CRC64;
     MVDEGTRKTL SSIPLLQTKA GPREKDLWVQ RLKEEYQALI KYVQNNKSSD SDWFRLESNK
     EGTKWFGTCW YVHNLLKYEF DVEFDIPVTY PATAPEIALP GLDGKTAKMY RGGKICLTDH
     FKPLWARNVP KFGIAHAMAL GLAPWLAVEI PDLIEKGVVT YKEKGETSG