UFC1_DANRE
ID UFC1_DANRE Reviewed; 166 AA.
AC Q6DEN0;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Ubiquitin-fold modifier-conjugating enzyme 1;
DE AltName: Full=Ufm1-conjugating enzyme 1;
GN Name=ufc1; ORFNames=dkey-71l1.2, zgc:100800;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: E1-like enzyme which specifically catalyzes the second step
CC in ufmylation. Accepts the ubiquitin-like modifier UFM1 from the E1
CC enzyme UBA5 and forms an intermediate with UFM1 via a thioester
CC linkage. Ufmylation is involved in reticulophagy (also called ER-phagy)
CC induced in response to endoplasmic reticulum stress.
CC {ECO:0000250|UniProtKB:Q9Y3C8}.
CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UFC1
CC subfamily. {ECO:0000305}.
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DR EMBL; BX901896; CAN88582.1; -; Genomic_DNA.
DR EMBL; BC077079; AAH77079.1; -; mRNA.
DR RefSeq; NP_001003650.1; NM_001003650.1.
DR AlphaFoldDB; Q6DEN0; -.
DR SMR; Q6DEN0; -.
DR STRING; 7955.ENSDARP00000036899; -.
DR PaxDb; Q6DEN0; -.
DR Ensembl; ENSDART00000037181; ENSDARP00000036899; ENSDARG00000022340.
DR Ensembl; ENSDART00000182860; ENSDARP00000154921; ENSDARG00000022340.
DR GeneID; 445256; -.
DR KEGG; dre:445256; -.
DR CTD; 51506; -.
DR ZFIN; ZDB-GENE-040801-268; ufc1.
DR eggNOG; KOG3357; Eukaryota.
DR GeneTree; ENSGT00390000008196; -.
DR HOGENOM; CLU_101170_0_0_1; -.
DR InParanoid; Q6DEN0; -.
DR OMA; IKYVQNN; -.
DR OrthoDB; 1339876at2759; -.
DR PhylomeDB; Q6DEN0; -.
DR TreeFam; TF313587; -.
DR PRO; PR:Q6DEN0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000022340; Expressed in swim bladder and 28 other tissues.
DR GO; GO:0061657; F:UFM1 conjugating enzyme activity; ISS:UniProtKB.
DR GO; GO:0071568; F:UFM1 transferase activity; IBA:GO_Central.
DR GO; GO:1990592; P:protein K69-linked ufmylation; IBA:GO_Central.
DR GO; GO:0071569; P:protein ufmylation; ISS:UniProtKB.
DR Gene3D; 3.10.110.10; -; 1.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR014806; Ufc1.
DR PANTHER; PTHR12921; PTHR12921; 1.
DR Pfam; PF08694; UFC1; 1.
DR PIRSF; PIRSF008716; DUF1782; 1.
DR SUPFAM; SSF54495; SSF54495; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..166
FT /note="Ubiquitin-fold modifier-conjugating enzyme 1"
FT /id="PRO_0000391955"
FT ACT_SITE 116
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3C8"
SQ SEQUENCE 166 AA; 19117 MW; 7BE211580E922006 CRC64;
MADEATRKAV SEIPLLKTNS GPRDKELWVQ RLREEYLALI KYVENNKAAD NDWFRLESNK
EGTRWFGKCW YIHELLKYEF DMEFDIPVTY PATAPEVAIP ELDGKTAKMY RGGKICLTDH
FKPLWARNVP KFGLAHLMAL GLGPWLAVEI PDLIAKGLIQ HKDQNS
