ID   UFC1_DROSI              Reviewed;         164 AA.
AC   B4QHD6;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Ubiquitin-fold modifier-conjugating enzyme 1;
DE   AltName: Full=Ufm1-conjugating enzyme 1;
GN   ORFNames=GD25576;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: E2-like enzyme which forms an intermediate with UFM1 via a
CC       thioester linkage. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UFC1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; CM000362; EDX07281.1; -; Genomic_DNA.
DR   RefSeq; XP_002081696.1; XM_002081660.2.
DR   AlphaFoldDB; B4QHD6; -.
DR   SMR; B4QHD6; -.
DR   STRING; 7240.B4QHD6; -.
DR   EnsemblMetazoa; FBtr0225486; FBpp0223978; FBgn0196862.
DR   GeneID; 6734689; -.
DR   HOGENOM; CLU_101170_0_0_1; -.
DR   OMA; IKYVQNN; -.
DR   PhylomeDB; B4QHD6; -.
DR   Proteomes; UP000000304; Chromosome 2r.
DR   Bgee; FBgn0196862; Expressed in embryo and 3 other tissues.
DR   GO; GO:0061657; F:UFM1 conjugating enzyme activity; IEA:InterPro.
DR   GO; GO:0071569; P:protein ufmylation; IEA:InterPro.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   InterPro; IPR014806; Ufc1.
DR   PANTHER; PTHR12921; PTHR12921; 1.
DR   Pfam; PF08694; UFC1; 1.
DR   PIRSF; PIRSF008716; DUF1782; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..164
FT                   /note="Ubiquitin-fold modifier-conjugating enzyme 1"
FT                   /id="PRO_0000391975"
FT   ACT_SITE        116
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   164 AA;  19018 MW;  C5C55F4E28F64F00 CRC64;
     MVDDSTRKTL SNIPLLQIRA GPREKDVWVQ RLKEEYQALI KYVENNKQSG SDWFRLESNK
     EGTKWFGKCW YMHNLLKYEF EVEFDIPVTY PTTAPEIALP ELDGKTAKMY RGGKICLTDH
     FKPLWARNVP KFGIAHAMAL GLAPWLAVEI PDLIEKGIIT YKEK