ID   UFC1_NEMVE              Reviewed;         169 AA.
AC   A7SM54;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Ubiquitin-fold modifier-conjugating enzyme 1;
DE   AltName: Full=Ufm1-conjugating enzyme 1;
GN   ORFNames=v1g214407;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: E2-like enzyme which forms an intermediate with UFM1 via a
CC       thioester linkage. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UFC1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; DS469705; EDO35210.1; -; Genomic_DNA.
DR   RefSeq; XP_001627310.1; XM_001627260.1.
DR   AlphaFoldDB; A7SM54; -.
DR   SMR; A7SM54; -.
DR   STRING; 45351.EDO35210; -.
DR   EnsemblMetazoa; EDO35210; EDO35210; NEMVEDRAFT_v1g214407.
DR   GeneID; 5506607; -.
DR   KEGG; nve:5506607; -.
DR   eggNOG; KOG3357; Eukaryota.
DR   HOGENOM; CLU_101170_0_0_1; -.
DR   InParanoid; A7SM54; -.
DR   OMA; IKYVQNN; -.
DR   OrthoDB; 1339876at2759; -.
DR   PhylomeDB; A7SM54; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0061657; F:UFM1 conjugating enzyme activity; IEA:InterPro.
DR   GO; GO:0071568; F:UFM1 transferase activity; IBA:GO_Central.
DR   GO; GO:1990592; P:protein K69-linked ufmylation; IBA:GO_Central.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   InterPro; IPR014806; Ufc1.
DR   PANTHER; PTHR12921; PTHR12921; 1.
DR   Pfam; PF08694; UFC1; 1.
DR   PIRSF; PIRSF008716; DUF1782; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..169
FT                   /note="Ubiquitin-fold modifier-conjugating enzyme 1"
FT                   /id="PRO_0000391960"
FT   ACT_SITE        116
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   169 AA;  19398 MW;  89491E5E09856B26 CRC64;
     MVDEATKKTL AAIPLLKTKA GPRDGKDWVD RLKEEYTSLI KYVSNNKEAD NDWFRLESNK
     EGTRWFGKCW YIHNLLKYEF DVEFDIPITY PTTAPEIALP ELDGKTAKMY RGGKICMTDH
     FKPLWGRNVP RFGIAHAMAL GLGPWLAVEI PDLIEKGLIK HKDKSESSR