ID   UFC1_OSMMO              Reviewed;         167 AA.
AC   C1BKD1;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Ubiquitin-fold modifier-conjugating enzyme 1 {ECO:0000305};
DE   AltName: Full=Ufm1-conjugating enzyme 1 {ECO:0000250|UniProtKB:Q9Y3C8};
GN   Name=ufc1 {ECO:0000250|UniProtKB:Q9Y3C8};
OS   Osmerus mordax (Rainbow smelt) (Atherina mordax).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Stomiati; Osmeriformes; Osmeridae;
OC   Osmerus.
OX   NCBI_TaxID=8014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RA   von Schalburg K., Leong J., Cooper G., Davidson W.S., Koop B.F.;
RT   "Osmerus mordax full-length cDNAs.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: E1-like enzyme which specifically catalyzes the second step
CC       in ufmylation. Accepts the ubiquitin-like modifier UFM1 from the E1
CC       enzyme UBA5 and forms an intermediate with UFM1 via a thioester
CC       linkage. Ufmylation is involved in reticulophagy (also called ER-phagy)
CC       induced in response to endoplasmic reticulum stress.
CC       {ECO:0000250|UniProtKB:Q9Y3C8}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UFC1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BT075060; ACO09484.1; -; mRNA.
DR   AlphaFoldDB; C1BKD1; -.
DR   SMR; C1BKD1; -.
DR   GO; GO:0061657; F:UFM1 conjugating enzyme activity; ISS:UniProtKB.
DR   GO; GO:0071569; P:protein ufmylation; ISS:UniProtKB.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; ISS:UniProtKB.
DR   GO; GO:0061709; P:reticulophagy; ISS:UniProtKB.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   InterPro; IPR014806; Ufc1.
DR   PANTHER; PTHR12921; PTHR12921; 1.
DR   Pfam; PF08694; UFC1; 1.
DR   PIRSF; PIRSF008716; DUF1782; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
PE   2: Evidence at transcript level;
KW   Ubl conjugation pathway.
FT   CHAIN           1..167
FT                   /note="Ubiquitin-fold modifier-conjugating enzyme 1"
FT                   /id="PRO_0000391957"
FT   ACT_SITE        116
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y3C8"
SQ   SEQUENCE   167 AA;  19261 MW;  BDF1B0CE1B373D31 CRC64;
     MADDATRKAV SDIPLLKTNS GPRDKELWVQ RLREEYLALI KYVENNKVAD NDWFRLESNK
     EGTRWFGKCW YIHDLMKYEF DVEFDIPVTY PTTAPEVAIP ELDGKTAKMY RGGKICLTDH
     FKPLWARNVP KFGLAHLMAL GLGPWLAVEI PDLISKGIVV HKEQQNN